Chiral recognition was observed in a biomembrane model. Micellar aggregates formed by enantiopure N-alkyl-N,N-dimethyl-N-(1-phenyl)ethylammonium bromide were in fact able to convert the racemic mixture of bilirubin-IXalpha into an enantiomerically enriched mixture. The stereochemical preference and the extent of enantiomeric enrichment depend on the length of the hydrophobic portion of the surfactant and on the concentration conditions, and changes in the stereochemical bias are reversible.

a b s t r a c tThis paper presents the theory of a novel mechanism of energy absorption and induced damping in structural systems and its application to aerospace industry. The underlying principles of the physical phenomena have been addressed in several earlier publications, which focused on prototypical systems of absorbers that consist of a set of single-degree-of-freedom resonators. This paper generalizes those theoretical developments to the case of a cluster of beams attached to a continuous primary structure, to develop predictive methods for the expected performance of this new type of absorber, with particular emphasis on its optimal design. An embodiment of the conceived device is illustrated for an aerospace structure, a satellite, with the purpose of reducing the vibration of the electronic components on board during lift-off. Experimental results illustrate the feasibility and the attractiveness of this new absorption technique.

The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the interaction with certain phospholipids. The extent of equilibrium displacement depends on the molecular structure of phospholipids and on the state of charge of bilirubin. The results obtained validate the hypothesis of a possible involvement of chirality in bilirubin toxicity and support a previously suggested model for the molecular mechanism of the interaction of bilirubin with the synaptic membrane.

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