Tonsillectomy resulted in altered tongue sensation in 28 per cent of our study group. Bipolar diathermy dissection was significantly more likely to cause altered sensation than cold steel dissection. Ninety-six per cent of these disturbances resolved by three months, all by one year. Possible alteration of tongue sensation should be discussed whilst obtaining consent for tonsillectomy.

SummarySimultaneous fluorescent [F] detection of the factor V Leiden (G1691A) and the prothrombin 3’-untranslated region (G20210A) mutations were performed in a single tube polymerase chain reaction (PCR). Amplification refractory mutation detection system (ARMS) formed the basis of this assay design. Fluorescent-labelled primers incorporated into amplicons during the reaction facilitated detection directly by GeneScan analysis without further manipulation. To test the efficacy of this double [F]-ARMS (dF-ARMS) method, 48 patients with unexplained thrombotic tendencies were investigated for their factor V Leiden and prothrombin genotypes. These results corresponded exactly with data achieved using the more conventional methods of restriction fragment length polymorphism (RFLP)-PCR and direct DNA sequencing. Three out of the 48 patients in this group were found to be compound heterozygotes.

No abstract

Summary Fifty‐eight children with acute haema‐togenous osteomyelitis have been studied. The incidence of infection by penicillin‐resistant organisms was found to be 54.5 % in 33 cases in which an organism was recovered. Tetracycline has been found to be more effective than penicillin in the primary treatment of this condition.

Actinomvcosis is now so widely known as a patilological entity that the presentation of four hours). Four months after injury the fracture was united, but the sinus over the greater trochanter continued to discharge. Six months after injury the cavity was laid widely open under VOL. 33B, NO. 2, MAY 1951 221 FIG. 1 222 C. H. CULLEN AND M. E. SHARP THE JOURNAL OF BONE AND JOINT SURGERY general anaesthetic through a transverse incision. Several sequestra were removed. Actinomvces, UNITS OF PENICILLIN PER CC.