No abstract

Disodium phosphonoacetate (PAA) was found to inhibit the replication of African swine fever virus (ASFV). The action of this compound has been compared with the inhibitory capacity of iododeoxyuridine (IDU) upon ASFV growing in Vero cells. The study was done by the immunofluorescence technique in order to detect formations of cytoplasmic virus antigens and inclusion bodies; both were found to be inhibited by IDU and PAA. At 100 µg/ml, IDU blocked completely the multiplication of ASFV and with PAA, a few scattered cells showed positive fluorescence. The infectivity of the virus was reduced 1–5 log depending upon drug concentrations and time of exposure to the drugs. Inhibition of ASFV replication by PAA suggests that this virus, like other herpesviruses, involves a virus-specific DNA polymerase in its replication mechanism.

No abstract

Monoolein, monolinolein and (most strongly) gamma-linolenyl alcohol inactivate ASF virus and inhibit its replication in Vero cells at 25 micrograms/ml while at 10 micrograms/ml no inactivation occurs but inhibition of replication in tissue culture is observed. This suggests two possibly different action mechanisms.