Introducción: Determinar si una dieta con germen de trigo (Triticum aestivum) tiene un efecto radio protector sobre el tejido miocárdico de ratas albinas (Rattus rattus var. Albinus) Método: Ratas con un peso entre 200 - 250 g fueron divididas en 4 grupos de 6 cada uno: Dos grupos fueron alimentadas con una dieta regular de germen de trigo durante 16 días antes y después de una única exposición a un grupo con 18 mSv de rayos X. Los otros dos grupos fueron alimentados con una dieta estándar, uno de ellos, fue expuesto a los rayos X. Los animales fueron sacrificados y se realizó un estudio histopatológico del tejido cardiaco. Resultados: Las ratas alimentadas con una dieta estándar y expuesta a los rayos X, presentaron marcada hiperemia de vasos sanguíneos, necrosis, presencia de fibrocitos en el tejido conectivo, pérdida de la arquitectura y disposición radial muscular. Las ratas expuestas y alimentadas con dieta de trigo presentaron solo una ligera necrosis y presencia de fibrocitos. Las ratas no expuestas a rayos X presentaron un miocardio saludable. Conclusiones: La dieta del germen de trigo puede tener un efecto radioprotector sobre el miocardio de rata.
Chagas disease, a parasitic infection caused by the protist Trypanosoma cruzi, affect the poorest populations, living in remote, rural areas and urban slums. Although this drug is effective against Chagas disease present a number of serious side effects. In residents of high Andean areas with megacolon it can lead to cardiomyopathies. The aim of this study was to investigate whether dietary supplementation with L-glutamine may alleviate some of these symptoms because of its previously observed anti-inflammatory properties. We studied two groups of T. cruzi-infected mice receiving treatment with nifurtimox. One group was fed the standard diet, while the other group’s diet was supplemented with Glutamine. We found that Glutamine supplementation increases body weight (p<0.001), decreases heart mass to body mass ratio (p<0.001), and decreases the number of amastigotes present in cardiac tissue. Additionally, histopathological analysis showed less heart tissue damage in the group that received Glutaminne in their diet. Therefore, our findings suggest that Glutamine supplementation improves nifurtimox treatment outcomes of T. cruzi infection.
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