Although a growing body of research evidence suggests that persons encountering stressful life circumstances are protected from potential declines in health and well-being by supportive relationships, the evidence for the stress-buffering qualities of social support for cancer patients is equivocal. This study examines the relationship between naturally occurring, supportive behaviors and psychological adjustment to the illness for 32 nonhospitalized adult cancer patients, and includes follow-up data collected 7 months after the initial interview. Results indicated that although support appeared to have few effects on adjustment at either time point for the sample as a whole, social support was related to poorer adjustment for patients not undergoing chemotherapy or radiation treatments, or for those with many limitations on physical functioning. These findings, though tentative because of the sample size, point to the need to consider the specific contextual stresses the cancer patient is experiencing in evaluating psychosocial adjustment to the illness, and suggest caution in assuming social supports to be a universal boon.