Blood smear evaluation of two baboons (Papio cynocephalus) experiencing acute hemolytic crises following experimental stem cell transplantation revealed numerous intraerythrocytic organisms typical of the genus Babesia. Both animals had received whole-blood transfusions from two baboon donors, one of which was subsequently found to display rare trophozoites of Entopolypoides macaci. An investigation was then undertaken to determine the prevalence of hematozoa in baboons held in our primate colony and to determine the relationship, if any, between the involved species. Analysis of thick and thin blood films from 65 healthy baboons (23 originating from our breeding facility, 26 originating from an out-of-state breeding facility, and 16 imported from Africa) for hematozoa revealed rare E. macaciparasites in 31%, with respective prevalences of 39, 35, and 12%. Phylogenetic analysis of nuclear small-subunit rRNA gene sequences amplified from peripheral blood of a baboon chronically infected withE. macaci demonstrated this parasite to be most closely related to Babesia microti (97.9% sequence similarity); sera from infected animals did not react in indirect fluorescent-antibody tests with Babesia microti antigen, however, suggesting that they represent different species. These results support an emerging view that the genusEntopolypoides Mayer 1933 is synonymous with that of the genus Babesia Starcovici 1893 and that the morphological variation noted among intracellular forms is a function of alteration in host immune status. The presence of an underrecognized, but highly enzootic, Babesia sp. in baboons may result in substantial, unanticipated impact on research programs. The similarity of this parasite to the known human pathogen B. microti may also pose risks to humans undergoing xenotransplantation, mandating effective screening of donor animals.

Having been at the centre of a century long debate which cast doubt on the nature of Augustine’s conversion, one might assume that Augustine’s early works (386-96) have now been rescued and given their rightful place. This book suggests that these are now threatened by an equally destructive trend in Augustine scholarship, which, over the last fifty years, has become an almost unquestioned norm of interpretation. This is the idea, fatefully and poignantly depicted by Peter Brown in the chapter of his seminal biography entitled The Lost Future, that the early optimistic and philosophical Augustine was dramatically transformed into the mature, pessimistic theologian of the Fall, original sin, and grace by his reading of Paul in the mid-390s. This interpretation of the first decade of Augustine’s life has since become such an idée fixe in scholarly as well as popular accounts, leaving two very different Augustines: one, the young convert, fired to pursue Wisdom by an optimistic confidence in the rational disciplines of the liberal arts, human free will, and a glorious ideal of perfection; the other, the older and wiser bishop of Hippo, convinced of human fallen ness and of the need for grace to will or to do any good work. This book argues that in order to do justice to Augustine’s conversion, to his early theology and understanding of the Christian life, and to the early works themselves, such caricatures must be resisted. It seeks to demonstrate that there is a fundamental continuity in Augustine’s thought, which does not undergo any dramatic change when he re-reads Paul in the 390s; that there is only one Augustine, for whom human weakness and divine grace were the central axes of his Christian faith and life from the very beginning.

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This book places Saint Augustine's theology in a new context by considering what he has to say about beauty. It demonstrates how a theological understanding of beauty revealed in the created, temporal realm enabled Augustine to form a positive appreciation of this realm and the saving power of beauty within it. It therefore reintroduces aesthetics alongside philosophy and ethics in Augustine's treatment of God. The book shifts emphasis away from Augustine's early and most theoretical treatises to his mature reflections as a bishop and pastor on how God communicates with fallen man. Using his theory of language as a paradigm, it shows how divine beauty, revealed in creation and history, serves to inspire fallen man's faith, hope, and most especially his love – thereby reforming him and restoring the form or beauty he had lost.

Data of high quality are critical for the meaningful interpretation of registry information. The National Joint Registry (NJR) was established in 2002 as the result of an unexpectedly high failure rate of a cemented total hip arthroplasty. The NJR began data collection in 2003. In this study we report on the outcomes following the establishment of a formal data quality (DQ) audit process within the NJR, within which each patient episode entry is validated against the hospital unit’s Patient Administration System and vice-versa. This process enables bidirectional validation of every NJR entry and retrospective correction of any errors in the dataset. In 2014/15 baseline average compliance was 92.6% and this increased year-on-year with repeated audit cycles to 96.0% in 2018/19, with 76.4% of units achieving > 95% compliance. Following the closure of the audit cycle, an overall compliance rate of 97.9% was achieved for the 2018/19 period. An automated system was initiated in 2018 to reduce administrative burden and to integrate the DQ process into standard workflows. Our processes and quality improvement results demonstrate that DQ may be implemented successfully at national level, while minimizing the burden on hospitals. Cite this article: Bone Jt Open 2022;3(9):716–725.