Objectives. A multidimensional scale was developed and tested to measure pharmacy students' proclivity toward becoming entrepreneurs within their chosen pharmacy work environments. Methods. A descriptive, cross-sectional design was used to survey a convenience sample of PharmD students attending a single public university during the spring semester of 2003. Results. The response rate was 77.5%, representing 66.7% to 100% of each of 4 PharmD classes. The resulting 3-factor, 23-item Pharmacy Student Entrepreneurial Orientation (PSEO) summated scale was shown to be reliable (Cronbach alpha = 0.9351) and normally distributed. Scale validity in this population was supported. Higher mean PSEO scores were found for students aspiring to pharmacy ownership (p<0.05) and unspecified business ownership (p<0.05), and for those who had led efforts to create change (p<0.01).Conclusions. Measuring entrepreneurial orientation may help to identify students inclined to be future entrepreneurs in the profession, inform academic advising efforts, and direct attempts to foster innovation by future pharmacists. new and creative use of resources 15 and in terms of the psychology or personality of individuals who may behave in these ways. 16 Its conceptualization has included individual, environmental, and organizational factors. 17 Intending to clarify the nuances of the related but different terms, a distinction between entrepreneurship and entrepreneurial orientation was put forth by Lumpkin and Dess. 17 They conceptualized entrepreneurship as representing new market entry, that is, what happens regarding new and creative resource use in the marketplace, and entrepreneurial orientation as describing how new entry is accomplished. Thus, entrepreneurial orientation is purported to embody the processes and requirements, as well as the intentions and behaviors, of key marketplace players that include 5 dimensions: the willingness to take risks (risk-taking) and innovate (innovativeness), proactive behaviors designed to find and act upon marketplace opportunities (proactiveness), the propensity to be autonomous (autonomy), and an aggressive tendency toward the competition (competitive aggressiveness). 17 In this study, the focus was on the processes and requirements of future new market entry as it pertains to students, thus focusing on individual students' entrepreneurial orientation. We define pharmacy student entrepreneurial orientation to be the beliefs, behavioral intentions, and self-reported behaviors that suggest a pharmacy student's proclivity to instigate new market-entry activities. In particular, the focus was on the case of developing new, innovative pharmacy services as a future pharmacist. Here, students' present day, self-described characteristics and behaviors, in addition to their behavioral intentions and beliefs about their future work as pharmacists, were included. Organizational and environmental influences on actual entrepreneurship within the health care marketplace were also acknowledged.Hypothesis testing was use...