Although conclusions are limited by small sample size and the possibility of a type II error, results suggest that short-term estrogen therapy does not improve symptoms of most women with AD. These findings do not address possible long-term effects of estrogen in AD, possible interactions between estrogen and other treatment modalities, or putative effects of estrogen in preventing or delaying onset of this disorder.

Background-Few longitudinal studies evaluate differences in patterns of change of category compared to letter fluency across the spectrum of cognitive impairment.

No abstract

In this article, the authors provide a comprehensive review of the research of mild head injury in children and adolescents from 1970 to 1995. Because of marked variability in methodologies across studies, a preliminary box-score tally was computed, without regard to studies' scientific or methodological merit. These results revealed 13 adverse, 18 null, and 9 indeterminate findings related to neuropsychological, academic, or psychosocial outcome. When studies were classified based on methodological merit, the stronger studies were generally associated with null outcomes across domains. However, a few of the less stronger neuropsychological studies (5 of 40) reported subthreshold and transitory alterations during the early postinjury period. At the present time, cautious acceptance of the null hypothesis is recommended until more definitive studies are conducted that address the problems raised in this review.