Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation.

Introduction: Montreal Cognitive Assessment (MoCA) is the most common cognitive screening instrument for Mild Cognitive Impairment detection. Although the current Brazilian version (MoCA-BR) has been validated, in clinical practice, it is observed that adults with normal cognitive function, especially those less educated, rarely reaches the maximum score of 30 points on the test. Objective: Introduce a methodology to adjust the Brazilian version according to the Brazilian culture. A cross-se Methods: ctional observational study was conducted with 294 participants. In the Memory section, we used the free listing technique to replace words. In the Naming section, an epidemiological survey of the most pinpointed gures was conducted. Replication of Sentence section was modied based on meetings between researchers and Portuguese teachers uent in English. The alternative version of MoCA-BR was composed by: "az Results: ul" (blue), "braço" (arm), "orquídea" (orchid), "seda" (silk) and “igreja” (church) in Memory Section; giraffe, elephant, and lion in the Naming section; “Eu só sei que é João quem será ajudado hoje” and "O gato sempre se esconde embaixo do sofá quando o cachorro está na sala" in the Replication of Sentence section. Our Conclusions: data reinforce the need to adapt the MoCA-BR. We present an alternative version of MoCA-BR, which contemplates the linguistic and cultural requirements of the transcultural adaptation process. The next step is to apply this version to obtain its validation. We believe that this adaptation may allow a future better applicability of the MoCA-BR, especially in less educated people, without underestimating the scores of cognitively normal individuals

Background: The current version of the Brazilian Montreal Cognitive Assessment (MoCA-BR) did not have a reliable cross-cultural adaptation to Brazil-ian Portuguese. In previous stages of this study, the Alternative Version of the MoCA-BR was developed, with changes in the sections: Memory and Delayed Recall, Language and Naming. Objectives: to verify the influence of crosscultural adaptation on the performance of cognitive tools, and the accuracy of the Alternative Version of the MoCA-BR. Methods: a pilot, prospective, longitudinal and analytical study. Both versions of the test were applied in a randomized and cognitively healthy population, between 18 and 60 years, within a medium interval of 54,56 days between the questionnaires. Results: out of 104 participants, 70 were included (64.3% female, 40.2 years). The alternative version obtained superior performances in the naming domain (p < 0.001), and in the adapted sentence in the language domain (p = 0.003). There was no significant difference in the delayed recall domain. The alternative version showed good internal consistency, with a Cronbach’s alpha of 0.75. The cutoff point suggested by the study is 27 points, with sensitivity and specificity of 91.3% and 79.2%, respectively. Conclusions: Cultural factors affect the accuracy of cognitive tests, and adaptation is essential for their use in different countries.