Lipids play an important role during pregnancy, and in this period major changes occur in lipoprotein metabolism. During the third trimester plasma cholesterol and triglyceride levels are substantially increased, returning to normal after delivery. Described associations between increased morbidity during pregnancy and excessive increases in plasma cholesterol and triglycerides. For this reason we have reviewed the relationship between lipid alterations, preeclampsia, gestational diabetes and preterm birth. The overall metabolic control can improve pregnancy outcomes, and the assessment of supraphysiological changes in lipid profile will classify pregnancy risk at a higher level, which would entail a stricter control.

Objective: To survey the accuracy of fetal gender determination during the first-trimester screening and scan for congenital anomalies. Method: A prospective observational study was performed on 496 singleton pregnancies at the first-trimester ultrasound screening. The doctor was certified by The Fetal Medicine Foundation (FMF). Ultrasound examination was performed on a GE Voluson 730 Pro transabdominally between 11-13 + 6 weeks. Both transverse and mid-sagittal planes of section of the fetal genital tubercle were done to identify the gender. The subsequent gender at birth was obtained from the karyotyping reports or the hospital birth records. Results: During the study 496 patients requested gender information at the time of first-trimester screening. Of those patients where it was possible to determine gender (441 out of 496) the scan achieved an overall success rate of 92.3% in correctly identifying gender. It was found that both transverse and mid-sagittal planes to identify fetal gender were necessary to improve determination. When the crownrump length was 45.0-56.0 mm, the accuracy rate was 75.4%, when the crown-rump length was 57.0-67.0 mm, the accuracy rate was 92.0% (P < 0.001), when the crown-rump length was 68.0-84.0 mm, the accuracy rate was rose to 98.3% (P < 0.001). The fetal gender accuracy rate for male fetus was slightly better than female (93.4% vs 91.2%) but is not statistically significant. Conclusion: This study demonstrated that the 11-13 + 6 weeks scan achieved an overall adjusted accuracy of 82.1% in correctly determining fetus gender. The gestation age of the fetus had a material effect on the accuracy rate of gender determination. P01.46The incidence and characteristics of first-trimester fetal lateral neck cysts J. Bellver, C. Lara, I. Alcover, F. F. Correa, A. Pellicer, J. Remohí, V. Serra Unidad de Medicina Materno-Fetal, Instituto Valenciano de Infertilidad, Universidad de Valencia, SpainObjective: To investigate the incidence and epidemiologic characteristics of fetal lateral neck cysts (FLNC) in the 11-13 weeks scan. Methods: A total of 3075 fetuses were scanned at our institution, between April 2001 and March 2006, for first-trimester Down syndrome screening. Ultrasound examinations were performed transvaginally and completed afterwards by the abdominal route. Results: FLNC were detected in 20 fetuses (incidence 0.65%). Diagnoses were performed mainly by transvaginal ultrasound between 12 + 4 and 13 + 4 weeks. There were 16 singleton and 4 twin fetuses. Thirteen were naturally conceived and 7 achieved after in vitro fertilization, two of them using ovum donation. FLNC were bilateral in 12 cases and unilateral in the remaining 8 (mainly left-sided). The mean (range) diameter was 3.2 mm (0.4-6.4 mm). Most were associated with a normal nuchal translucency (NT) measurement (16/20). The remaining 4 cases had a NT > p95 (2.5-3.7 mm). Other associated findings were: absent nasal bone (1 case), abnormal ductus venosus flow (2 cases) and mild bilateral renal pyelectasis (2 cases). Only 3 ...

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We report on the prenatal diagnosis through array CGH of a dichorionic–diamniotic (DC/DA) twins discordant for Cri du Chat Syndrome. Structural anomalies on one of the twins lead to amniotic fluid sampling, which revealed a partial deletion on the short arm of the chromosome 5. Selective feticide of the affected twin was performed at 34 + 1 weeks' and elective Cesarean section at 37 + 2 weeks. Postnatal cytogenetic analysis confirmed pre-natal genetic findings.

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