SUMMARY:The present French and European measles outbreaks show a bimodal distribution: the two most affected populations are infants aged less than 1 year and adults older than 20 years. The purpose of this study was to determine wether there were differences in the clinical presentation and evolution of measles between adult and pediatric patients. We performed a retrospective study of adult and pediatric measles patients admitted to three tertiary-level university hospitals between January 2008 and May 2011. Data were extracted from medical charts and positive laboratory results. Collected data were age, sex, geographical origin, vaccination status, source of exposure, overseas travel before symptom onset, clinical symptoms, risk factors for complications, severity criteria on admission, type of diagnosis, biological abnormalities, complications, and treatments. A total of 305 patients (171 children and 134 adults) were included in the study. The mean age was 4.6 ± 4.4 years in children and 26.7 ± 8.1 years in adults. Children were less often hospitalized than adults (29z vs. 66z). A comparison between hospitalized pediatric (n ＝ 49) and adult (n ＝ 89) patients revealed that the former had a higher incidence of complications ( P º 0.0001), more otorhinolaryngological complications (24z vs. 1z; P º 0.0001), and a higher incidence of severe criteria on admission ( P ＝ 0.02). Hospitalized pediatric patients differed from adults in terms of disease severity and complications.