Anophthalmia is the absence of an eye. This may be unilateral or bilateral and its prevalence is low. It results from developmental arrest of the globe during organogenesis. Three patients aged 22, 23 and 25, sisters, have congenital unilateral right-sided, bilateral and unilateral left-sided anophthalmia respectively. The only family history element is that their paternal great-grandfather also suffered from congenital unilateral right-sided anophthalmia. They were sent from the Regional Clinical Hospital to the Clinic of Trauma and Maxillofacial Prosthetics at Universidad de Concepción to be treated from their first months of life. The treatment included the use of sequential conformers to expand the eye sockets, and then individual ocular prostheses were prepared and installed. The rehabilitation of congenital anophthalmia is a major challenge. Early intervention, as was the case with these patients, makes a significant difference on the overall development of the patient and on the emotional well-being of the family.