The Iberian lynx, the most endangered cat in the world, is presently found only in two isolated populations in southern Spain. Natural expansion from these populations is limited which turns Iberian lynx reintroduction programs into the only alternative to save the species from extinction. Prey availability is one of the top considerations for predator reintroductions. In this paper, we review the state of the art regarding wild rabbit (lynx's main prey) biology, status and management in the Iberian Peninsula, and future perspectives for Iberian lynx conservation. Historically, wild rabbits have sharply declined in the Iberian Peninsula, mainly as a consequence of habitat loss and the arrival of viral diseases. Most Iberian rabbit populations are still declining so different management techniques are employed to revert this scenario. Population monitoring, adjusting hunting pressure, predator control, habitat management, restocking and rabbit vaccination are the most frequently employed management tools. Surprisingly, strong empirical evidence is still lacking to support the usefulness and impact of most of these management techniques. Hence, for the success of future Iberian lynx reintroductions, efforts need to be made to suppress knowledge gaps of rabbit ecology and management at several levels, namely: the study of basic biological parameters from natural free populations, the implementation of an Iberian rabbit monitoring framework based on standardised rabbit monitoring protocols (that produces systematic and periodic comparable results), the study of the impact of predator control, the assessment of both the costs vs. benefits of vaccinating wild rabbits against viral diseases and the effectiveness of habitat management. Finally, the creation of a working platform congregating researchers, hunters and game managers, conservationists and further sectors involved in wild rabbit management is essential for the definition of a global strategy that defends collective interests and serves the ultimate goal of conserving this lagomorph.