Summary. The guinea-pig uterine artery responded to acetylcholine (ACh) with vasodilatation only during pregnancy or after oestrogen treatment. Even with high doses (1 mg/day) oestradiol-17\g=b\ esters had to be administered for several days to effect sensitization to ACh, but oestradiol-17\g=b\ itself was active within a few hours. Oestriol was equipotent with oestradiol. Sensitization was prevented when protein synthesis was inhibited over the period of oestrogen administration, but was not dependent on the integrity of the cholinergic vasodilator nerve supply to the artery.
Clients referred to the CAMHS' AIM team displayed a pattern of multiple risk factors and comorbidities. Low caseload of 8-10 clients per clinician allowed flexibility and a level of intensity to make any necessary changes in service provision to better suit the client's needs. The majority of clients showed improvement in functioning following intervention by the team.
The paper presents a model of care focusing on family emotions in the treatment of adolescent obsessivecompulsive disorder, which is illustrated by a case study. It is concluded that augmenting current treatments by targeting family emotions may enhance adolescent outcomes and improve family functioning. The model is illustrated by a case study, and further systematic research with a larger sample size is recommended.
She has worked as a pediatric nurse practitioner in Oregon and California where she primarily worked with high-risk pediatric clients in rural, urban, and academic settings. She is currently working on her Doctorate of Nursing Practice at University of San Francisco, with particular research interest in community-based care of the high-risk pediatric client.
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