Activity data from two experimental lizard groups were analysed in order to search for 24 hentrained and ultradian periodicities. The data of a first group were obtained through motion sensitive platforms situated under the animals' cage and continuously for up to 12 consecutive days; those from a second group were collected by manual recording of the behaviour patterns of individual animals for 2 h each day over a 10-day period. Lizards from both groups were situated in cages inside isolated chambers in which a light-dark cycle (12:12), a temperature of 28°C ±1° and a relative humidity of 50-60% were maintained. Periodogram analysis showed the existence of a significant period peak (p < 0.01) at 24 h. Autocorrelation functions and spectral analysis of different data-segment lengths showed that ultradian periodicities were present in the daily motor activity, appearing as noisy though frequency-band limited. Differences in the frequency bandlimited fluctuations were found between morning and afternoon activities: during the morning ultradian activity appears distributed in two bands (4.5-36 c/day and 63-94 c/day), the power being mainly concentrated in the second one, while during the afternoon it was in the 4.5-36 c/day band. Results from the second lizard group showed only one band (24-60 c/day) overlapped with the first one from the latter group. Although activity recording methods and some experimental conditions are discussed as possible sources of these differences, the possibility of endogenous ultradian variation within the individuals is also suggested.

The Duane-Radial Ray syndrome or Okihiro syndrome belongs to the SALL4-Related Disorders, a phenotypic spectrum, that additionally includes, acrorenoocular syndrome and Holt-Oram syndrome, caused by the alteration of the same gene, which has signifi cant relevance in the mesoderm, the limbs, and the heart development. These syndromes are characterized by thumb alteration, radial deviation of the forearm, Duane anomaly, and variable involvement of other organs such as kidney or heart. The prevalence is unknown. This is a case report of a Chilean patient with a pathogenic variant that confi rms the Duane Radial Ray syndrome previously not described in the population.