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Four research studies of students and faculty engaged in fully online undergraduate courses are analyzed to generate best practices for teaching and learning online. These studies investigated the relationship of student background variables and online behaviors to student persistence and achievement in the online environment. Over 500 students enrolled in lower division, undergraduate courses offered online were included in the analyses. The courses were designed by faculty and instructional design experts and met standards of quality course design established by the offering colleges and universities. By combining the results of the study, guidelines for advising students and faculty for success in the online environment emerged.

This research empirically examined student behavior in online courses and its relationship to persistence and achievement across fields. Eight variables descriptive of student behaviors online were measured for 1) frequency and 2) duration of participation. Twenty-two courses were grouped into three broad fields: English and Communication; Social Sciences; and Math, Science, and Technology. The descriptive data revealed significant differences in student online participation, persistence, and achievement across the fields. Multiple regression analyses were used to evaluate how well student participation measures predicted achievement. Depending on the field, different portions of the variability in achievement were accounted for by student participation measures.

BackgroundPreeclampsia, preterm birth and low birth weight represent key contributing factors to perinatal morbidity and mortality. Pregnancies complicated by type 1 and type 2 diabetes are at increased risk of these complications, which are purported to be largely attributed to placental dysfunction. Studies investigating a potential role for aspirin therapy in optimizing perinatal outcome have consistently failed to demonstrate a benefit among women with pre-existing diabetes, and yet widespread aspirin administration has become common practice in many centres. This study seeks to examine the effect of aspirin therapy, administered from the first trimester until 36 weeks gestation, on perinatal outcome in women with established pre-pregnancy diabetes. Our hypothesis is that aspirin therapy will reduce complications mediated by placental dysfunction, and improve perinatal outcomes.MethodsThis phase III double-blinded, placebo-controlled randomized clinical trial will be conducted in seven tertiary-level perinatology centres in Ireland. Consenting participants who meet all eligibility criteria will be allocated randomly to either aspirin 150 mg once daily or matching placebo, commenced between 11 + 0 and 13 + 6 weeks. Allocation will take place electronically using software by Clininfo with randomization tables provided by the trial biostatistician. The primary outcome will be a composite clinical measure of placental dysfunction (preeclampsia, preterm birth before 34 weeks, birthweight below the 10th centile or perinatal mortality). This trial has been set up such that it is parallel in design and is a superiority study. No participants have been recruited yet. The trial has been registered with Eudra Clinical Trials - EudraCT Number 2018-000770-29. Funding for this trial was granted by the Health research Board (HRB) 1/9/2017(DIFA-2017-026).DiscussionAspirin therapy has been investigated for the prevention of preeclampsia owing to its reduction on thromboxane production. Previous studies have failed to demonstrate a beneficial effect of aspirin on perinatal outcome amongst women with type I or type II diabetes. It is plausible that the failure to observe benefit to date, among the limited aspirin studies that have included participants with diabetes, may be a consequence of aspirin initiation too late in pregnancy to exert any effect on placentation. We believe that if aspirin is to be used for the prevention of placental dysfunction, it must be initiated before the second active phase of trophoblast invasion, which takes place from 14 weeks’ gestation onwards. No randomized trials investigating the role of aspirin in prevention of preeclampsia in pregnancies complicated by diabetes have previously initiated treatment in the first trimester, the gestational period at which it is most likely to exert an effect on placentation.