Skin, the largest organ of the human body, is exposed daily to environmental aggressors such as solar radiation and air pollution, resulting in many acute and chronic conditions. [1][2][3] The damaging effects of UV radiation on skin include erythema (sunburn), pigmentation (tanning), photocarcinogenesis, and photoaging. [4][5][6][7] Other exposomal factors such as air pollution, 8-11 tobacco smoke, 12 infrared radiations (IRs), 13,14 ozone, 15 and alcohol consumption 16 also have detrimental effects on skin health. 17 From a mechanistic point of view, all these environmental threats seem to involve oxidative stress as one common denominator. Interestingly, most of the skin's solar exposure throughout the lifetime is incidental, under normal conditions when no sunscreens are used. 18 Preventative strategies such as the use of sun protective clothing, avoiding sun exposure, and the use of sunscreens are ideal for photoprotection. In the Western world, where sunbathing and tanning are popular, combined with the global lack of consumer awareness for adequate or frequent use of sunscreens, these strategies are often rendered ineffective.In the absence of any topical photoprotective intervention, skin's primary defense solely rests on endogenous protection.

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