A simple method to convert readily available carboxylic acids into sulfinate salts employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent TFCS-Na. The reactivity of six of these salts towards C–H functionalization was field-tested using several different classes of heterocycles.

A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS‐Na. The reactivity of six of these salts towards CH functionalization was field‐tested using several different classes of heterocycles.

Sulfinates are readily available from carboxylic acids using classic Barton chemistry. The sulfinates are used to functionalize a diverse range of heterocycles of potential interest in medicinal chemistry. -(GIANATASSIO, R.; KAWAMURA, S.; EPRILE, C. L.; FOO, K.; GE, J.; BURNS, A. C.; COLLINS, M. R.; BARAN*, P. S.; Angew. Chem., Int. Ed. 53 (2014) 37, 9851-9855, http://dx.