Background: Evidence for vitamin B 12 deficiency usually involves combinations of low serum vitamin B 12 levels, clinical and metabolic abnormalities, and therapeutic response. Identification of the underlying cause is important in the diagnosis of vitamin B 12 deficiency that is usually attributed to malabsorption. Helicobacter pylori is one of the most common causes of peptic ulcer disease worldwide and a major cause of chronic superficial gastritis leading to atrophy of gastric glands. It is suggested that there may be a casual relationship between H pylori and food-cobalamin malabsorption.

As a result, we found no correlation between platelet aggregation responses obtained with optical method and platelet indices proposed as indicators of certain pathologic conditions, and it does not seem possible to use platelet indices as a direct indicator of platelet activation. In conditions where platelet functions should have been assessed, platelet indices alone are inappropriate and further evaluation is necessary with different methods.

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: Recently, several studies about mean platelet volume (MPV) changes in various pathological conditions were published. The aim of this study was to evaluate the accuracy of the measurement in these studies. The study was performed using the data of 181 studies containing a healthy control groups within 1181 studies about MPV indexed PubMed database since 2012. A total of 81 studies were included retrospectively. The distributions of sex, age, and platelet counts were not reported in 16, 12, and 28 studies, respectively. Type of anticoagulant was not noted in 60 studies. The technology used was not specified in 36 studies. The MPV values measured with Sysmex were significantly higher than measured with Beckman Coulter, Abbott CELL-DYN, and Siemens ADVIA. The MPV measurements varied up to 17.8% by the instruments. The measurement times between 15 min and 2 h was significantly different from the measurement times less than 15 min and more than 2 h. The MPV measurement times from venipuncture were not indicated in 86 studies (47.5%). Maximum deviations in MPV measurements by the MPV measurement times and plus the instruments used varied up to 17.8 and 27.7%, respectively. Both the MPV measurement times and instruments used were not stated in 29 studies (16.0%). Only 47 prospective studies (26.0%) enlightened about the type of anticoagulant, instruments used for MPV measurement, MPV measurement time, platelet counts, and MPV values. As a result, the measurements were not standardized sufficiently in published studies about MPV. It may be explained that the differences between the results of studies made the same pathological conditions.

Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean platelet volume (MPV), in pre-eclamptic and normal pregnant women and to evaluate whether these parameters have a prognostic significance in determining the severity of eclampsia. The study and control groups consist of 56 pre-eclamptic and 43 normal pregnant women, respectively. There was no statistically significant difference according to CBC, platelet count and MPV when pre-eclamptic and severely pre-eclamptic patients were compared with controls. As a result, we observed no prognostic significance of CBC, platelet count and MPV on the presence and/or severity of pre-eclamptic condition. There are conflicting results especially on the significance of MPV in the literature, and possibly this confliction is due to the difference between methods and/or equipments used for automated blood count.