A região Norte do Brasil é considerada zona endêmica de diversas doenças infectocontagiosas, das quais podemos citar a meningite. A doença possui diversos fatores causais, sendo que a etiologia viral é a mais comum, porém a de origem bacteriana apresenta-se como responsável pela maior taxa de mortalidade. Entretanto, apesar da sua relevância no contexto de saúde pública na região Norte do país, poucos são os estudos publicados sobre a meningite na região. Nesse sentido, foi realizado um estudo transversal com o objetivo de traçar o perfil dos indivíduos acometidos por essa doença no Norte do Brasil entre os anos de 2012 e 2015. Os dados foram obtidos no banco de dados oficial do Sistema de Informação de Agravos de Notificação (SINAN). No período de estudo, ocorreu queda no número de casos notificados, houve predominância do sexo masculino, da faixa etária entre 0 e 19 anos e de etiologia bacteriana. Este trabalho, associado a estimativas globais, pode fornecer subsídios para ações de prevenção e controle da meningite na região Norte.     Palavras-chave: Meningite; Região Norte; Brasil; Epidemiologia. ABSTRACT Northern region of Brazil is considered an endemic area of several infectious diseases, such as meningitis. The disease has several causal factors, and the viral etiology is the most common, but the bacterial origin is responsible for the highest mortality rate. However, despite its relevance in the context of public health in the northern region of the country, there are a few published studies on meningitis in the region. So, a cross-sectional study was carried out with the objective of tracing the profile of the individuals affected by this disease in Northern Brazil between the years of 2012 and 2015. Data were collected from the official database of the notification of injury information system. During the study period, there was a decrease in the number of cases reported, there was a predominance of males, ages ranging from 0 to 19 years and bacterial etiology. This work, combined with global estimates, can provide subsidies for prevention and control of meningitis in the North.                                   Keywords: Meningitis; Northern Brazil; Epidemiology.

Direitos Autorais: © 2017 Rodrigues Junior et al. Este é um artigo de acesso aberto que permite o uso, a distribuição e a reprodução sem restrições em qualquer meio, desde que o autor original e a fonte sejam creditados. Conflito de interesses ABSTRACTSchistosomiasis is an endemic disease in Brazil. It is caused by the worm Schistosoma mansoni, presenting itself as a serious public health problem. However, despite the relevance of the disease, there are few studies about the disease in the northern region of Brazil, so the present study aimed to evaluate the epidemiological characteristics of schistosomiasis in the region between 2012 and 2015. A cross-sectional study of the information collected in the bank of the national health information system, of the Ministry of Health. During this period, there was a trend in the growth of reported cases in the region, with 65,09% observed in males and 34, 91% of the female sex, 71,60% of the brown race, 17,16% of the white race, 71,01% were urban dwellers and 26,63% were rural. In addition, the majority of the population studied was between 20 and 59 years old. According to previously published studies, there is a trend of increasing incidence of human infection by Schistosoma sp. This perspective of growth of reported cases can be observed in the data found by this study, relevant data for providing information for the construction of control and prevention policies.

A Síndrome de Turner é caracterizada citogeneticamente pela presença de um cromossomo X e perda total ou parcial do segundo cromossomo sexual, ocorrendo em aproximadamente 1:2.130 nascidos vivos do sexo feminino. A Tireoidite de Hashimoto é um distúrbio autoimune decorrente de resposta imune anormal à glândula tireoide, tanto do ponto de vista humoral como celular. A doença de Crohn é uma doença crônica recidivante que afeta todas as partes do tubo digestivo, sendo multifatorial, em que fatores de ordem genética, imunológica e ambientais têm uma relevância preponderante no início e na perpetuação da lesão tecidual imunomediada. O objetivo deste trabalho foi relatar o caso de três pacientes de uma mesma família. Caso 1, primeira gemelar (dizigótica), 8 anos de idade, sexo feminino, com diagnóstico de Tireoidite de Hashimoto. Caso 2 (segunda gemelar), sexo feminino, com o diagnóstico de Síndrome de Turner. Caso 3 (primogênita), sexo feminino, com diagnóstico de Doença de Crohn.  Duas filhas de um casal hígido manifestaram doenças autoimunes, as quais têm incidência aumentada na síndrome de Turner. Doenças endócrinas autoimunes possuem mecanismos complexos com a participação de vários fatores, como a susceptibilidade genética, eventos ambientais e resposta autoimune, porém, neste caso, não se encontrou história familiar positiva além da geração estudada. Outros estudos familiares, como este que se propõe, com múltiplos membros acometidos, poderão identificar associações cada vez mais consistentes entre essas doenças, além daquelas ainda não suspeitadas.   Palavras-chave: Síndrome de Turner, Tireoidite de Hashimoto, Doença de Crohn, Hereditariedade. ABSTRACT Turner syndrome is characterized cytogenetically by the presence of an X chromosome and total or partial loss of the second sex chromosome, occurring in approximately 1:2,130 live female births. Hashimoto's Thyroiditis is an autoimmune disorder resulting from an abnormal immune response to the thyroid gland, both from a humoral and cellular point of view. Crohn's disease is a chronic recurrent disease that affects all parts of the digestive tract, being multifactorial, in which genetic, immunological and environmental factors have a preponderant relevance at the beginning and the perpetuation of immune-mediated tissue injury. The objective of this study was to report the case of three patients from the same family. Case 1, first twin (dizygotic), 8 years old, female, with diagnosis of Hashimoto's Thyroiditis. Case 2 (second twin), female, with the diagnosis of Turner Syndrome. Case 3 (first-born), female, with diagnosis of Crohn's Disease. Two daughters of a healthy couple have manifested autoimmune diseases, which have an increased incidence in Turner syndrome. Autoimmune endocrine diseases have complex mechanisms with the participation of several factors, such as genetic susceptibility, environmental events and autoimmune response, but in this case, no positive family history was found beyond the generation studied. Other family studies, such as this one proposed, with multiple affected members, will be able to identify increasingly consistent associations between these diseases, in addition to those not yet suspected. Keywords: Turner syndrome, Hashimoto's thyroiditis, Crohn's disease, Heredity.