No abstract

The wound healing activity of topically applied extract of bark of Ziziphus jujuba was evaluated in albino rat by excision wound model for a period of 24 days. In this study, the rats were divided into four groups, each groups continued healing process with 5 and 10% w/w methanolic extract of Ziziphus jujuba mg/cm 2 . Test duration was 24 days, wound diameter measurement using digital image analysis on days 0, 8 th , 16 th , 21 st and 24 th with biopsy of two rats from each group were taken. The results revealed that treatment with low-dose group of methanolic extract of Ziziphus jujuba (5%) less shrinkage of wound area and also from the perspective of Histopathological change. In the second and third week, tissue had better organization than most other groups (p<0.01), but the group treated with high doses of methanolic extract of Ziziphus jujuba (10%) had most wound shrinkage and organization.