Abstract:Retroperitoneal fibrosis (RPF) is a rare disease. The objective of this paper is to study the prevalence, clinical, biological and radiological aspects of the RPFand to specify its therapeutic modalities. This study provides descriptive evidence for a series of 20 patients with RPF. We conducted a retrospective study of cases of RPF diagnosed in the Urology and Internal Medicine departments of the Ibn Sina Military Hospital in Marrakech over a five-year period from July 2010 to December 2015. The positive diagnosis of RPF was retained either on the basis of a histological analysis from a biopsy fragment or, in the absence of histological evidence, by the detection on a scan of an infiltrate or "sleeve" Regular and homogeneous tissue density, perivascular topography, surrounding the abdominal aorta, more or less extended to the iliac vessels and able to take the contrast after injection. They were 15 men and 5 women with an average age of 53 years with extremes of 41 to 74 years. Almost all patients had mainly lumbar and abdominal pain. An inflammatory syndrome existed in all cases and renal insufficiency in 15 cases. Radiological investigations showed unilateral or bilateral hydronephrosis in 16 cases. RPF was idiopathic in 14 patients. Secondary forms were present in 6 patients (three atheromatous diseases, one gastric tumor, one case associated with Riedel's thyroiditis and one case of systemic fibrosis associating RPF, Riedel's thyroiditis and liver fibrosis). The treatment consisted of corticosteroids in 19 cases, surgery in 17 cases associated with corticosteroid therapy or even immunosuppressant in the case of steroid-dependence. Two deaths were observed in this series; one of these two patients had developed cervix carcinoma with pleural and peritoneal metastases after 5 years of immunosuppressive therapy. The second died due to the complications of his gastric neoplasm. The general characteristics of patients included are similar to the other series of the literature. The frequency of secondary forms seems to be underestimated, hence the value of a rigorous etiological investigation. The therapeutic strategy and the use of the cortisone saving treatments should be specified by randomized therapeutic trials. The prognosis is generally good; however, the possibility of recurrences, the incidence of which is greater during the first five years, requires prolonged clinical, biological and radiological monitoring.

Keyword:-Hépatite c -diabète type II.Type 2 diabetes and hepatitis C virus (HCV) infection are two of the most important problems of public health in the world. A relationship between these two diseases has been discussed by several teams in the literature. However, risk factors for this association remain unsolved. The main purpose of our study was to estimate the prevalence of HCV in the population with type 2 diabetes. The present study is an observational descriptive transversal study conducted between June 2012 and December 2012 in the department of EndocrinologyDiabetology and Metabolic Diseases in the Military Hospital Avicenna of Marrakesh. After explaining the objectives of our study to patients, who had to express by writing their consent, we collected information about the demographic data, socio-economic data, family antecedents of type 2 diabetes and risk factors for HCV infection. Then, all patients underwent a complete clinical examination. The search for anti-VHC Antibodies, the assessment of liver function and glycemic balance were performed on all patients. Research and quantification of viral RNA were routinely done to patients with anti-

Summary: Tuberous sclerosis (TS) is a rare genetic disease of autosomal-dominant transmission. Mutations in either the tuberous sclerosis complex 1 (TSC1) or tuberous sclerosis complex 2 (TSC2) genes result in hamartomas affecting many organs, such as the brain, heart, kidneys, skin, lungs and liver. We report the observation of a 17-year-old girl with facial angiofibromas, hypo-pigmented skin lesions on the lower back and back of the right wrist and a history of seizures. The patient was admitted to the emergency department for treatment-resistant status epilepticus and was referred to our training for magnetic resonance imaging (MRI) of the brain. Brain MRI revealed subependymal nodules, cortical tubercles, and white matter abnormalities.