Objective: To identify the prevalence of urinary incontinence, the distribution of the type of urinary incontinence and related risk factors in women older than 50 years. Method: This is a descriptive study with cross sectional design. Two hundred and seventy eight women older than 50 years old living in nursing home were interviewed using the Questionnaire for Urinary Incontinence Diagnosis (QUID) that has been translated and validated. The prevalence will be presented in the form of percentage; while the relationship between risk factors and the incidence or urinary incontinence will be analyzed using Chi square test or Fisher’s exact test, as appropriate, and multivariate analysis. Result: Of 278 research subjects, we obtained 95 subjects (34.2%) suffering from urinary incontinence. Moreover, the distribution of the type is 67 subjects (70.5%) with mixed urinary incontinence, 17 (17.9%) with stress incontinence and 11 subjects (11.6%) with urge incontinence. Body mass index (BMI) showing overweight and obesity are not related with the prevalence of urinary incontinence (p>0.05), which may be caused by the low number of subjects with overweight and obesity. Meanwhile, factors related to urinary incontinence are age older than 60 years (OR=7.79, p=0.021), menopause 10 years (OR=5.08, p=0.004) and multiparity (OR=1.82, p=0.019). Based on multivariate analysis, the risk factor of age older than 60 years is no longer related to urinary incontinence (p>0.05). Thus it can be inferred that age older than 60 years is not a singular factor causing urinary incontinence but rather a part of a multifactorial model. Conclusion: This study shows that the prevalence of urinary incontinence in women living in nursing home is 34.2%; while the distribution of the urinary incontinence is 67 subjects (70.5%) with mixed urinary incontinence, 17 subjects with stress incontinence (17.9%) and 11 subjects (11.6%) with urge incontinence. Risk factors for urinary incontinence are menopause 10 years and multiparity. [Indones J Obstet Gynecol 2014; 4: 193-198 Keywords: mixed urinary incontinence, menopause, multiparity, prevalence, stress incontinence, urge incontinence, urinary incontinence, Questionnaire for Urinary Incontinence Diagnosis (QUID)

Synthesis of 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone and evaluation of their antioxidant activity have been carried out. 3-Chloro-4-hydroxy-5-methoxybenzaldehyde was obtained through chlorination of vanillin using Ca(ClO)2, while 3-bromo-4-hydroxy-5-methoxybenzaldehyde was obtained via bromination of vanillin using KBrO3 in glacial acetic acid solvent and 47% HBr catalyst. Then, 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxychalcone was prepared from 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2-4-dihydroxyacetophenone through Claisen-Schmidt condensation in the presence of KOH (40%) base and KSF montmorillonite in methanol. Elucidation of the structure of these compounds was performed using FTIR, GC-MS, TLC-Scanner, MS-Direct, 1H-NMR, and 13C-NMR. The synthesized benzaldehydes and chalcone were tested for their antioxidant activities using DPPH method, where 2,6-di-tert-butyl-4-methylphenol (BHT) was used as positive control. The results showed that 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone were obtained in 53%, 97%, and 1%, respectively. The antioxidant activity assay showed that BHT, 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone displayed the IC50 of 27.94, 244.11, 269.44 and 162.10 µg/mL, respectively.