This paper deals with the problem of non-linear landmark-based registration of CT (at two different instants of the breathing cycle, intermediate expirations) and PET images of thoracic regions. We propose a general method to introduce a breathing model in a registration procedure in order to simulate the instant in the breathing cycle most similar to the PET image and guarantee physiologically plausible deformations. Initial results are very promising and demonstrate the interest of this method to improve the combination of anatomical and functional images for diagnosis and oncology applications.

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Self-disturbance is recognized as a key symptom of Borderline Personality disorder (BPD). Although it is the source of significant distress and significant costs to society, it is still poorly specified. In addition, current research and models on the aetiology of BPD do not provide sufficient evidence or predictions about who is at risk of developing BPD and self-disturbance, and why. The aim of this review is to lay the foundations of a new model inspired by recent developments at the intersection of social cognition and behavioural ecology. We argue that the sense of agency is an important dimension to consider when characterizing self-disturbances in BPD. Second, we address the poorly characterized relation between self-disturbances and adverse social conditions encountered early in life. We highlight the potential relevance of the phenotypic plasticity framework in evolutionary biology to make sense of this association. We suggest that the effect of early life adversity on BPD symptomatology depends on the way individuals trade their limited resources between competing biological functions along the life cycle.