The aim of the present study was to improve the solubility and bioavailability of a poorly water-soluble drug in human body, using a solid dispersion technique (hot melt extrusion). The solid dispersion was prepared by cooling the hot melt of the drug in the carrier (Vitamin E TPGS and PVP). The dissolution rate of formulation 1 from a novel formulation prepared by solid dispersion technique was equal to release of formulation 6 (40% of eprosartan mesylate is in contrast to teveten ®) within 60 min (Table 1). The oral bioavailability of new eprosartan mesylate tablet having vitamin E TPGS and PVP K29 was tested on rats and dogs. Of the absorption enhancer and polymer tested, vitamin E TPGS and PVP K29, resulted in the greatest increases of AUC in animals (about 2.5-fold increase in rat and dog). When eprosartan mesylate was mixed with the absorption enhancer and polymer in a ratio of 2.94:2:1, vitamin E TPGS and PVP K29 improved eprosartan mesylate bioavailability significantly compared with the conventional immediate release (IR) tablet Teveten ® (formulation 7). These results show that solid dispersion using vitamin E TPGS and PVP K29 is a promising approach for developing eprosartan mesylate drug products.

Background and Objectives: The purpose of this study was to compare the effects of using real objects and voice output aids(VOCAs) for non-symbolic communicators with severe cerebral palsy. Method: Participants were two non-symbolic adolescents with severe cerebral palsy who had not used AAC aid. This study used alternating treatments design (ATD) between sessions. The intervention was composed with baseline, treatment Ⅰ, generalization Ⅰ, treatment Ⅱ, generalization Ⅱ and a maintenance phase. The intervention strategies were composed of the most-to-least prompt system in the treatment Ⅰ and the least-to-most prompt system in the treatment Ⅱ. Results: First, two adolescents revealed higher requesting in real objects than VOCAs at the beginning of intervention, but revealed higher requesting using VOCAs in generalization. Second, at the beginning of intervention, two adolescents barely produced spontaneous vocalization but revealed higher spontaneous vocalization using VOCAs than real objects in generalization. Conclusion: AAC intervention with VOCA impacted on an increase in requesting and spontaneous vocalization of adolescents with severe cerebral palsy. AAC intervention was needed for non-symbolic communicators to get the cause-and-effect concept and to develop into symbolic communicators.

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