A low dose of sublingual misoprostol appears to be as effective as a low dose of i.v. methylergometrine in the prevention of post-partum hemorrhage in low-risk cases. So given the advantages of its stability at room temperature, low cost and easy route of administration, misoprostol appears to be a better choice, and a low dose is enough. However, larger studies in low-risk as well as high-risk cases are needed to advocate routine use of a low dose at the primary level.

Objectives: Present prospective study was carried out to know the frequency of transplacental fetomaternal hemorrhage in pregnancies complicated by third trimester vaginal bleeding and it's correlation with fetoneonatal outcome. Material methods: One hundred, out of 170 Rh-positive primigravida/multigravida with singleton pregnancy of more than 28 weeks gestation, admitted with third trimester vaginal bleeding with no other obstetric disorder, were the study subjects and 100 controls were women with no bleeding, admitted immediately after the study case with same inclusion and exclusion criteria. Maternal peripheral blood was collected at admission and at 2 hours of delivery and volume of FMH was calculated by Kleihauer's formula. Results: Statistically significantly more perinatal deaths occurred in women with FMH, 35% in study subjects compared to 2.7% amongst controls. Conclusion: In the cases of third trimester bleeding and fetomaternal hemorrhage, chances of perinatal deaths are more.

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