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BACKGROUNDAcute kidney injury (AKI) is characterised by sudden impairment of kidney function resulting in the retention of nitrogenous and other waste products normally cleared by the kidneys as well as impairment of acid-base balance, and water homeostasis. AKI is not a single disease but, rather, a designation for a heterogeneous group of conditions that share common diagnostic features. When this impairment is prolonged, erythropoietin secretion by this organ is decreased and toxic metabolites accumulate and cause haematological changes including decrease in Hb, HCT, MCH, MCV, RBC and platelet counts. This study evaluates haematological profile in patients with acute kidney injury.

BACKGROUNDCoronary artery disease remains the dominating cause of death in the world. Despite understanding and controlling the known risk factors for coronary artery disease, it remains the worldwide epidemic. This raises the possibility of the presence of unknown or underestimated risk factors. The role of uric acid as a prognostic factor in patients with acute coronary syndrome is controversial. The aim of the present study is to estimate serum uric acid levels in acute coronary syndrome and its correlation with Killip's classification of heart failure and in hospital mortality.

BACKGROUND Acute Kidney Injury (AKI) is a rapid and usually reversible decline in glomerular filtration rate (GFR) that may occur in the setting of either preexisting normal kidney functions or pre-existing damaged kidney. AKI in the ICU is associated with mortality as high as 45-50%, with dialysis dependence, with reduced quality of life, and with excess utilization of health resources. The aim of this study was to analyse the incidence, prognostic factors, and outcome of AKI in critically ill patients in the setting of a medical ICU. MATERIALS AND METHODS A single centered prospective observational study was carried out at Silchar Medical College and Hospital, Silchar, Assam for a period of 2 years 2015-2017. A total of 200 patients with AKI, defined by RIFLE criteria, during this period, who met our study requirements were evaluated. RESULTS AKI was predominantly encountered in older males. Diabetes, hypertension, coronary artery disease were the most commonly prevalent comorbidities. Sepsis was the most common cause of AKI, accounting for 38.6% of patients. RRT was required by 34.5% patients. In the hospital, mortality was 32.5%. CONCLUSION AKI has a tremendous effect on prognosis. Septic AKI exerts an important and independent increase in the risk for hospital death. A meticulous approach is needed for the better outcome in ICU settings.

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