Fmoc-amino acid chlorides were employed in the solid phase synthesis of the opioid peptides [Leulenkephalin. [ Leulenkephalin amide, and derniorphin. The conventional polystyrene-based Merrifield resin or Wang's resin served as solid support. A binary salt of either triethylaniine or diisopropylethylamine in the presence of I-hydroxybenzotriazole or pivalic acid was used for acylation. The coupling rates were quite fast, being comparatively faster when 1-hydroxybenzotriazole was used along with triethylaniine or diisopropylethylamine. The peptides obtained in good yields showed, after purification, biological and spectral properties identical with those of the natural peptides.Keil iwrh: amino acid chlorides: binary salt; coupling rate; ((9-fluoreny1methyl)oxy)carbonyl-amino acids: 1 -hydroxybenzotriazole: solid phase peptide synthesis

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