Background and Objective: The rheumatoid arthritis is autoimmune disease and it is a major health issues among the peoples in worldwide. People affected by rheumatism have double risk of heart disease, lungs and chest infections, which causes 10-20% of deaths in individuals. The present research work was aimed to evaluate the antiarthritic potential of synthesized silver nanoparticles from the aqueous extract of M.concanensis leaves. Material and Methods: The arthritis was induced by complete freund’s adjuvant method and the rats was treated with synthesized silver nanoparticles from aqueous extract of M.concanensis leaves. The body weight, paw volume, hematological parameters, liver function marker enzymes and the renal function markers of the arthritic rats and nanoparticles treated rats was analyzed by the standard methods. Results: The results of the present study were made the new findings in antiarthritic activity of silver nanoparticles from M.concanensis leaves. The nanoparticles showed a noteworthy antiarthritic activity against FCA induced rheumatoid arthritis in experimental rats. Conclusion: Based on the above results, it was concluded as the present work are states the better understand on the antiarthritic activity of silver nanoparticles of Moringa concanensis Nimmo leaves.

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Snakebite is one of the important medical problems that affect the public health due to their high morbimortality. Most of the snake venoms produce intense lethal effects, which could lead to impermanent or permanent disability or in often death to the victims. The accessible specific treatment was using the antivenom serum separated from envenomed animals, whose efficiency is reduced against these lethal actions but it has a serious side effects. In this circumstance, this review aimed to provide an updated overview of herbal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with prominence on plants inhibiting the lethal effects of snake envenomation amongst the rural tribal peoples of India. There are several reports of the accepted use of herbal plants against snakebites worldwide. In recent years, many studies have been published to giving pharmacological confirmation of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In India, a variety of herbal plants are used to cure against the snakebites and other poisonous bites, used either in alone or in combination with other herbal agents. The present study was designed to formulate an attempt to bring together information on medicinal plants that are grown and used for snakebite treatment in India. From a variety of literature sources, data have been compiled with prominence on the plants, family, parts used, etc., depending on the availability of information.

Snake envenomations have been a serious yet often overlooked public health threat especially in tropical and subtropical countries, including Southeast Asia. The medically important venomous land snakes in Southeast Asia include snakes from the Elapidae and Crotalidae families. Among the elapids, there are only 12 species that are considered of medical importance, represented by the kraits (Bungarus caeruleus, B. candidus, B. fasciatus, B. flaviceps and B. multicinctus). The incidence of snakebite is high in India. Apart from mortality, the morbidity is due to various complications. The common krait (Bungarus caeruleus) is the most toxic snake found commonly in the plains of throughout the India and the number of snakebites in the rural areas of India was recorded by this snake. The present article highlights the prevalence and the clinical complications of Indian common krait envenomation among the rural populations of India.

Indian saw-scaled viper are one of the highly venomous snake found in Indian subcontinent and its venom has a wide variety of toxic compounds and it can able to causing severe envenoming characterized by severe pharmacological effects. The traditional knowledge on the Acalypha fruticosa plant was clearly states that this plant was used against the venomous bites and stings. In best of our knowledge, there were no any scientific reports to justify the anti-snake venom potential of this plant. The main objective of the present research work was to evaluate the anti-snake venom activity of A. fruticosa against Indian saw-scaled viper venom using envenomed animal model. The effects of ethanolic leaves extract of A. fruticosa on hematological parameters of experimental rats, saw-scaled viper venom induced liver toxicity, renal toxicity and blood metabolites was analyzed in experimental rats. In the present study, the ethanolic leaves extract of A. fruticosa leaves was inhibited the venom induced changes in hematological parameters. The plant extract was effectively decreased the saw-scaled viper venom induced liver toxicity and renal toxicity in experimental rats. The observed results clearly states that the A. fruticosa leaves has potent snati-snake venom activity.