tional Chinese medicine-paiteling, which is composed of a crude alcoholic extract of honeysuckle, Folium isatidis, kuh-seng and Brucea javanica among others. Paiteling can quickly cross the epidermal cell space to reach the basal layer of the epidermis without damaging the dermis and the subcutaneous tissue, 5 and promotes the exfoliation of the epidermal cells in GCA. 6 The method of drug administration is also important. Doctors must master the drug penetration concentration, administration times and intervals, among others, in order to optimize the effect of the drug.

Objective Our study sought to investigate the clinical influencing factors of psoriasis patients with depression, and analyze whether the content of monoamine neurotransmitters in plasma was correlated with depression incidence among psoriasis patients. Methods Ninety patients with psoriasis and 40 healthy volunteers (aged from18 to 60) were recruited and interviewed with a piloted questionnaire in both groups to obtain relevant information. The catecholamine in plasma from the two groups was analyzed by radioimmunoassay. The data were analyzed by SPSS statistical software. Results The mean Hamilton Depression Scale (HAMD) and mean Athens Insomnia Scale (AIS) scores of the psoriasis patients were higher than the control group. Dopamine content in the plasma was lower (comparing psoriasis patients without depression and the control group, and was negatively correlated with HAMD, AIS, and Psoriasis Area and Severity Index (PASI) scores in the psoriasis patients with depression. There was no significant difference in the epinephrine and norepinephrine contents in all groups. PASI scores were positively correlated with HAMD scores in psoriasis patients. The low dopamine content, Dermatology Life Quality Index, and high PASI scores were the risk factors for depression among the psoriasis patients. Conclusion Psoriasis patients have a significantly higher risk of depression than healthy people, and higher PASI scores were linked to a higher incidence of depression. The dopamine levels of patients were influenced by both psoriasis and depression. The risk factors for depression in psoriasis patients are low dopamine levels in the plasma, severe skin lesions, and lower quality of life.

A case of giant condyloma acuminatum (Buschke-Lowenstein tumor) successfully treated with acitretin Dear Editor, Buschke-Lowenstein tumor is a rare variant of genital warts, initially described by Buschke and Loewenstein as a potential malignant condyloma acuminatum. It is usually caused by human-papilloma virus (HPV) type 6 and 11 infection. Treatment can be complicated or challenging due to the large size, long courses, degree of invasion, and high recurrence rate. There are few reports on the treatment of Buschke-Lowenstein with repeated recurrence in China. Here, we present a case who was successfully treated with Acitretin in the Outpatient. [1][2][3][4][5][6][7] A 54-year-old man found perianal papules 1 year ago without pain. The patient was diagnosed with condyloma acuminatum and treated with carbon dioxide laser before he came to our Outpatient, but the recurrence occurred after 2 weeks. His lesions appeared again, and the number of the new lesions exceeded 20, which made him suffer with severe obstructed defecation.Routine laboratory investigations, including a complete blood count, blood chemistry and urinalysis, were found to be within normal limits. Serological tests for syphilis and HIV infection were negative, and no abnormalities in various biochemical indicators. Physical examination showed no obvious abnormalities in the heart, lungs, and abdomen. Anal examination revealed a giant cauliflower-like lesion covered the whole perianal circle areas (5 × 4 cm), and the surface is rough and uneven, tender (+) as shown in Figure 1. Besides, the

Objective The present study investigated the clinical characteristics and gender differences of acne vulgaris associated with insulin resistance (IR).Methods The present study was conducted in 100 patients, comprising 52 males and 48 females, having acne vulgaris. Of the total, 18 male patients and 9 female patients exhibited IR, whereas 34 male patients and 39 female patients exhibited non-IR (NIR). The height, weight, acne grade, sex hormone, lipid metabolism, plasma glucose, and insulin levels of all the patients were measured and statistically analyzed.Results In the male group, the body mass index of the group with IR was significantly higher than that of the group with NIR (P < 0.05). No significant difference was observed in the sex hormones and insulin-like growth factor-1 (IGF-1) between female patients having acne associated with IR and those having acne associated with NIR. Levels of testosterone and sex hormone-binding globulin in male patients having acne associated with IR were lower than those in patients having acne associated with NIR, whereas the estrogen and IGF-1 levels in male patients with acne in the IR group were higher than those in the NIR group. Significant differences were observed in the fasting plasma glucose and fasting and 2-h postprandial plasma insulin levels between male and female groups (P < 0.05).Conclusion Disorders of sex hormone in male patients with acne vulgaris are related to IR; however, this correlation is not significant in women. Levels of sex hormones and metabolism in male patients having acne associated with IR must be actively monitored, and appropriate intervention must be administered.