A highly stereoselective total synthesis of (+)-lycoricidine has been described. The salient features of this synthesis are the one-pot elimination followed by allylation reaction, ring-closing metathesis, stereoselective aziridine formation, Dess-Martin periodinane, and silica gel mediated oxidative ring-opening of aziridine to form alpha,beta-unsaturated ketone (allyl amine) and intramolecular Heck cyclization.

A simple two‐step procedure which involves oxdiation of alcohols, derived from (D)‐(+)‐mannose, and silica gel mediated regioselective ring opening of the resulting ketones provides amines such as (II) and (V).