magnified image Synthesis of some novel N‐substituted 2‐(chroman/6‐bromochroman‐2‐yl)‐1H‐benzimidazoles by the condensation of 3,4‐dihydro‐2H‐chroman‐2‐carboxylic acid and 6‐bromo‐3,4‐dihydro‐2H‐chroman‐2‐carboxylic acid with o‐phenylenediamine in ionic liquid (IL) [bmim]BF4 and subsequent reactions at the benzimidazole‐NH with different types of electrophiles in ILs [bmim]BF4 = 1‐butyl‐3‐methylimidazolium tetrafluoroborate, [bmim]PF6 = 1‐butyl‐3‐methylimidazolium hexafluorophosphate and [buPy]BF4 = butylpyridinium tetrafluoroborate in the presence of sodium hydroxide as a base have been reported. All the synthesized compounds were screened for their antibacterial activity. Some compounds exhibited promising antibacterial activity against Staphylococcus aureus and Salmonella typhimurium when compared to Cephalexin as a reference standard. J. Heterocyclic Chem., (2010).

A series of some novel 2‐(substituted biphenyl) benzimidazoles and their N‐substituted derivatives were synthesized via microwave‐mediated Suzuki‐Miyaura coupling of 2‐(4‐iodophenyl)‐1H‐benzimidazole or 2‐(4‐iodophenyl)‐6‐amino‐1H‐benzimidazole and arylboronic acids. The method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Salmonella typhimurium bacterial species. J. Heterocyclic Chem., (2011).

Synthesis of Some Novel N-Alkyl/Acyl/Aroyl 2-(Chroman/6-bromochroman--2-yl)-1H-benzimidazoles Using Ionic Liquids and Their AntibacterialActivity. -The title compounds (V) and (VIII) display good antibacterial activity against S.aureus but they are less active against S. typhimurium when compared to the reference standard. The recovered ionic liquids are reused successfully with only a slight loss in yield. -(RAUT, C. N.; BAGUL, S. M.; JANRAO, R. A.; VAIDYA, S. D.; KUMAR, B. V. S.; MAHULIKAR*, P. P.; J.

A rapid and efficient method for the synthesis of novel 2-[6-(arylethynyl)pyridin-3-yl]-1H-benzimidazole derivatives under microwave-assisted Sonogashira coupling conditions has been developed. The method avoids the use of protecting groups for benzimidazole NH during Sonogashira coupling. The microwave-assisted method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates.

Derivatives. -Novel 2-biaryl-benzimidazoles (V) and (VII) are prepared via microwave-assisted Suzuki-Miyaura coupling followed by alkylation and acylation, respectively. All synthesized compounds are screened for their antibacterial activity against S. aureus and S. typhimurium. -(RAUT, C. N.; BHARAMBE, S. M.; PAWAR, Y. A.; MAHULIKAR*, P. P.; J. Heterocycl. Chem. 48 (2011) 2, 419-425, http://dx.doi.org/10.1002/jhet.610 ; Sch. Chem. Sci., North Maharashtra Univ., Jalgaon 425 001, India; Eng.) -H. Haber 33-107