In this paper, we established a theoretical model to investigate the local heating effect of magnetic nanoparticles (MNPs) aggregate on the support lipid bilayers (SLBs) under external alternating current (AC) magnetic field, which may be helpful to understand hyperthermia at single cell level. Using atomic force microscope (AFM), the transformation of the support phospholipid bilayers surrounding MNPs aggregate was observed in real-time. We found that the fluidity of lipid bilayers changed when the size of MNPs aggregate larger than 200 nm, as a result of magnetic heating in the AC magnetic field. These experimental data were consistent with the simulation results, which demonstrated the valid of our established model, as well as described more realistically the above phenomenon.

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