An aerosol-spray-assisted approach (ASAA) is proposed and confirmed as a precisely controllable and continuous method to fabricate amorphous mixed metal oxides for electrochemical water splitting. The proportion of metal elements can be accurately controlled to within (5±5) %. The products can be sustainably obtained, which is highly suitable for industrial applications. ASAA was used to show that Fe6Ni10O(x) is the best catalyst among the investigated Fe-Ni-O(x) series with an overpotential of as low as 0.286 V (10 mA cm(-2)) and a Tafel slope of 48 mV/decade for the electrochemical oxygen evolution reaction. Therefore, this work contributes a versatile, continuous, and reliable way to produce and optimize amorphous metal oxide catalysts.

Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism and involved in many diseases, including cancer. CFIm25, a subunit of the cleavage factor I encoded by NUDT21, is required for 3'RNA cleavage and polyadenylation. Although it has been recently reported to be involved in glioblastoma tumor suppression, its roles and the underlying functional mechanism remain unclear in other types of cancer. In this study, we characterized NUDT21 in hepatocellular carcinoma (HCC). Reduced expression of NUDT21 was observed in HCC tissue compared to adjacent non-tumorous compartment. HCC patients with lower NUDT21 expression have shorter overall and disease-free survival times than those with higher NUDT21 expression after surgery. Knockdown of NUDT21 promotes HCC cell proliferation, metastasis, and tumorigenesis, whereas forced expression of NUDT21 exhibits the opposite effects. We then performed global APA site profiling analysis in HCC cells and identified considerable number of genes with shortened 3'UTRs upon the modulation of NUDT21 expression. In particular, we further characterized the NUDT21-regulated genes PSMB2 and CXXC5. We found NUDT21 knockdown increases usage of the proximal polyadenylation site in the PSMB2 and CXXC5 3' UTRs, resulting in marked increase in the expression of PSMB2 and CXXC5. Moreover, knockdown of PSMB2 or CXXC5 suppresses HCC cell proliferation and invasion. Taken together, our study demonstrated that NUDT21 inhibits HCC proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5, and thereby provided a new insight into understanding the connection of HCC suppression and APA machinery.

BackgroundGastrointestinal cancers (GICs) mainly including esophageal, gastric and colorectal cancer, are the most common cause of cancer-related death and lead into high mortality worldwide. We performed this systematic review and meta-analysis to elucidate relationship between multiple microRNAs (miRs) expression and survival of GIC patients.MethodsWe searched a wide range of database. Fixed-effects and random-effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival. In addition, funnel plots were used to qualitatively analyze the publication bias and verified by Begg's test while it seems asymmetry.Results60 studies involving a total of 6225 patients (1271 with esophageal cancer, 3467 with gastric cancer and 1517 with colorectal cancer) were included in our meta-analysis. The pooled hazard ratio values of overall survival related to different miRs expression in esophageal, gastric, colorectal and gastrointestinal cancer were 2.10 (1.78-2.49), 2.02 (1.83-2.23), 2.54 (2.14-3.02) and 2.15 (1.99-2.31), respectively. We have identified a total of 59 miRs including 23 significantly up-regulated expression miRs (miR-214, miR-17, miR-20a, miR-200c, miR-107, miR-27a, etc.) and 36 significantly down-regulated expression miRs (miR-433, let-7g, miR-125a-5p, miR-760, miR-206, miR-26a, miR-200b, miR-185, etc.) correlated with poor prognosis in GIC patients. Moreover, 35 of them revealed mechanisms.ConclusionOverall, specific miRs are significantly associated with the prognosis of GIC patients and potentially eligible for the prediction of patients survival. It also provides a potential value for clinical decision-making development and may serve as a promising miR-based target therapy waiting for further elucidation.

In this article, AgVO3@AgBr@Ag nanobelt heterostructures were fabricated as an efficient visible-light photocatalyst through a hydrothermal process, an anion-exchange reaction, and a light-induced reduction. SEM and TEM characterization revealed that anion exchange followed by light-induced reduction is an efficient method to synthesize well-dispersed AgBr@Ag nanoparticles on the surface of AgVO3 nanobelts. The composite photocatalyst efficiently combines visible-light active AgBr and AgVO3 with the surface plasmon resonance (SPR) effect of Ag nanoparticles. The obtained catalyst displayed a high performance for removing organic dye in the range of visible light. This improved visible-light response likely originates from a synergistic effect of the different components. This work provides a versatile approach for accessing efficient, stable, and recyclable visible-light-driven plasmonic photocatalysts.

An aerosol‐spray‐assisted approach (ASAA) is proposed and confirmed as a precisely controllable and continuous method to fabricate amorphous mixed metal oxides for electrochemical water splitting. The proportion of metal elements can be accurately controlled to within (5±5) %. The products can be sustainably obtained, which is highly suitable for industrial applications. ASAA was used to show that Fe6Ni10Ox is the best catalyst among the investigated Fe‐Ni‐Ox series with an overpotential of as low as 0.286 V (10 mA cm−2) and a Tafel slope of 48 mV/decade for the electrochemical oxygen evolution reaction. Therefore, this work contributes a versatile, continuous, and reliable way to produce and optimize amorphous metal oxide catalysts.