Antisolvents increase the supersaturation in the crystallization process which can enhance the product yield. The effect of an antisolvent on the solubility of g-DL-methionine (g-DL-met) in aqueous solution was investigated. The solubility of g-DL-met was measured with various binary solvent mixtures. It improved with higher temperature but decreased with increasing the antisolvent mass fraction. Acetone showed the highest efficiency to reduce the solubility. The solubilities were correlated with the van't Hoff-Jouyban-Acree model and the modified Apelblat-Jouyban-Acree model. Both models fitted to the experimental results with high accuracy. Enthalpy, entropy, and Gibbs free energy of dissolution were determined by van't Hoff analysis. The thermodynamic properties indicated that the dissolution process is endothermic and entropy-driven.
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