Objective. To study the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Decoction in the treatment of patients with advanced ovarian cancer. Methods. 220 patients with advanced (stages III to IV) ovarian cancer in our hospital from May 2015 to October 2018 were selected and randomly divided into a control group and an observation group, with 110 cases in each group. The patients in the control group received basic nursing care and treatment with Bushen Quyu Decoction, and the patients in the observation group were combined with psychological intervention and dietary guidance on the basis of the treatment of the patients in the control group. The clinical efficacy, nursing satisfaction, treatment compliance, quality of life, negative emotion comparison, and long-term efficacy of the two groups were compared. Moreover, the changes of immune function indexes and the content of tumor markers were compared between the two groups. Results. The total effective rate of treatment in the observation group (64.55%) was higher than that in the control group (31.82%). The nursing satisfaction of the observation group was 94.55%, the nursing satisfaction of the control group was 84.55%, and the difference was statistically significant p < 0.01 . The treatment compliance of the observation group was 98.18%, the treatment compliance of the control group was 82.73%, and the difference was statistically significant p < 0.0001 . After nursing, the Anxiety Self-Rating Scale (SAS) score and Self-Rating Depression Scale (SDS) score of the two groups of patients were decreased ∗ p < 0.05 , and the score of the observation group decreased more significantly p Δ < 0.05 . After nursing, the scores of the two groups of patients in social/family status, physical function, physiological function, and emotional status increased ∗ p < 0.05 , and the observation group was significantly higher than the control group p Δ < 0.05 . After nursing, the CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than the control group p < 0.05 . The CD8+ level of the observation group was significantly lower than the control group p < 0.05 . After nursing, the levels of tumor markers in the two groups were decreased ∗ p < 0.05 , and the observation group was downregulated more significantly than the control group p Δ < 0.05 . The two-year cumulative survival rate of the observation group was 78.18%, and the two-year cumulative survival rate of the control group was 54.55%. The observation group was significantly higher than the control group p < 0.05 . Conclusions. Psychological intervention combined with dietary guidance can significantly improve the quality of life and mental state of patients with advanced ovarian cancer, enhance the patient’s immune function, reduce the serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA199) levels, and improve survival rate and survival time, which has important clinical significance.

This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene products in tumor biopsy samples, identifying biomarkers of prognosis and treatment response, to relatively noninvasive liquid biopsy assays, building on what we have learned in our tumor analysis and growing into its own evolving predictive and prognostic subspecialty. Hence, the field of GI precision oncology is exploding, and this review endeavors to summarize where we are now in preparation for the journey ahead.

Objective: To investigate the clinical value of using preoperative nutritional risk screening and support in gastric cancer patients. Methods: In this paper, 70 gastric cancer patients selected from July 2017 to July 2020 treated in our hospital were grouped concerning the lottery method, and the reference group (n=35) used conventional nutritional support, while the experimental group (n=35) used preoperative dietary risk screening and support, comparing the clinical treatment differences between gastric cancer patients in the experimental group and the reference group. Results: After the intervention, IgA, IgM, IgG, serum albumin, complication rate, NRS score, hospitalization time and anal exhaust time of gastric cancer patients in the experimental group were compared with those in the reference group, P<0.05, and there was statistical validation analysis significance between the data indicators. P<0.05 for the comparison of IgA, IgM, IgG, serum albumin after the intervention and pre-intervention for gastric cancer patients in the experimental group and the reference group, with statistical validation analysis significance between the data indicators. Conclusion: Preoperative nutritional risk screening and support is of significant value in gastric cancer patients and can improve patients' nutritional status.

Gastro-oesophageal cancer (GEC) is one of the world's deadliest forms of cancer. The conventional multi-modality approach to oesophageal cancer includes surgical resection, radiation and chemotherapy. However, due to the often-advanced nature of GEC on diagnosis, the limited efficacy of conventional therapies and the severe side effects of conventional treatments, the reported results are underwhelming. In the pursuit of better systemic therapies, targeted agents have played a vital role in GEC management. Said therapies essentially inhibit pathways such as the human epidermal growth factor receptor-2, vascular endothelial growth factor, epidermal growth factor receptor and programmed death receptor 1/programmed death-ligand 1 (i.e. immunotherapies). This review outlines a clinical summary of the most recent breakthroughs in targeted therapy for GEC and their associated clinical data, including efficacy and safety profiles.