Cervical cancer (CC) ranks as the second most lethal tumor derived from women in the world, only behind breast cancer, seriously threatening female health. 1 According to statistical data, there were exceeding 3.4 × 10 4 death caused by CC in China only in 2015. 2 Although the application of human papillomavirus (HPV) vaccines has effectively decreased the occurrence of CC, the prognosis of CC patients at advanced stages is still terrible. 3,4 Therefore, elucidating the mechanism underlying CC initiation and development is advantageous to develop new strategies of CC therapy.Circular RNAs (circRNAs) can be divided into non-coding cir-cRNAs and coding circRNAs. [5][6][7] They are characterized by a unique closed continuous ring structure and therefore exhibit more stability than their hosting gene under RNase R treatment. 8 A plethora of cir-cRNAs endows potential importance in human malignancies, serving as cancer biomarkers, and acting as cancer promoters or suppressors. 9 Mechanistically, as sponges of microRNAs (miRNAs), circRNAs

The ISIS Canada Networks of Centres of Excellence (NCE) program has focused on two main themes to improve civil engineering infrastructure, namely innovative construction technologies, and structural health monitoring (SHM). The former began with the construction of the first field application of the innovative steel-free concrete bridge deck slab technology at the Salmon River bridge, Nova Scotia, in 1995. Although this bridge has continued to function safely under heavy traffic loads, it has developed characteristic longitudinal cracking of the concrete between adjacent girders due to fatigue. This paper describes the recent research to develop an SHM model for monitoring the impact and stability of this cracking. Theoretical and experimental models were used to examine the change in response as cracking develops. A global load distribution matrix was proposed, and the variation in load distribution values with cracking was used to develop a cracking index that can be employed in monitoring the field structure.Key words: structural health monitoring, bridges, concrete, deck slabs, cracking, load distribution.

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An overmoded coaxial Ku-band relativistic backward wave oscillator (RBWO) with high efficiency is proposed. The distance between the inner and outer conductors of the slow wave structure (SWS) in the RBWO is smaller than the space wavelength of output microwave. The overmoded structure can increase the power capacity of the oscillator by increasing the transversal size of the device. The higher-order modes are introduced into the beam-wave interaction region intentionally, so that the intense relativistic electron beams (IREB) interacts with the fundamental and higher-order modes. Dual-mode operation leads impure mode component to output microwave, so the simple trapezoid inner conductor is designed to achieve mode purification and output pure TEM mode. The extractor is added at the end of the SWS, which enhances the axial electric field near the location and increases the modulation depth of the electron beam current passing through the region. The particle-in-cell (PIC) simulation results show that under the input power of 3.5 GW, the output microwave power is 1.8 GW, and the corresponding working efficiency is 51.4%, which is much higher than that of similar periodic devices. The mode of output microwave is pure TEM mode, and the maximum surface electric field intensity is 0.96 MV/cm, which means that the probability of radio-frequency breakdown is low.