A simple and efficient method for the direct synthesis of nitriles from aldehydes using ammonium acetate as the nitrogen source, iodine as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant was developed.

No abstract

An efficient method to prepare nitriles from aldehydesu sing hexamethyldisilazane (HMDS) as the nitrogen source hasb een developed. Ther eactions were performed with 2,2,6,6-tetramethylpiperidine l-oxyl (TEMPO) as the catalyst, NaNO 2 or TBN as the co-catalyst, andm olecular oxygena st he terminal oxidant under mild conditions.Avariety of aromatic, heteroaromatic, aliphatic anda llylica ldehydes could be converted into their corresponding nitriles in good to excellent yields.

Following an environmentally friendly, practical procedure a broad range of functionalized aryl, hetaryl, alkenyl, and alkyl aldehydes are efficiently oxidized to the corresponding nitriles.