Background: This study was to establish nomogram models for prognostic evaluation of early-onset gastric cancer (EOGC) in both overall survival (OS) and cancer-specific survival (CSS). Methods: EOGC patients from 2004 to 2015 were retrieved from the surveillance, epidemiology and end results (SEER) and further randomly assigned to training and validation sets. Univariate and multivariate cox analysis was used to screen out significant variables for construction of nomogram. Nomogram models were assessed by concordance index (C-index), calibration plot, receiver operating characteristics (ROCs) curve and decision curve analysis (DCA). Results: A total of 549 EOGC were selected in this process. OS nomogram was constructed based on tumor size and tumor site. CSS nomogram was constructed based on tumor size, SEER stage and tumor site.In training set, C-index for the OS nomogram was 0.688 [95% confidence intervals (95% CI): 0.629-0.747], CSS nomogram 0.785 (95% CI: 0.735-0.835). In the external validation, the C-index for the OS nomogram was 0.633 (95% CI: 0.579-0.687), while for the CSS nomogram 0.733 (95% CI: 0.686-0.780). High quality of calibration plots both in OS and OS nomogram models was noticed. Nomograms displayed a comparable result to tumor-node-metastasis (TNM) stage and SEER stage for EOGC based on DCA. Conclusions:The nomogram models provided an insightful and applicable tool to evaluate the prognosis of EOGC both in OS and CSS.

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We found a weak evidence for an inverse association between asthma and H. pylori infection both in children and in adults.

Background: Prognostic biomarkers remain a focus in breast cancer during last decades. More reliable predictors to adequately characterize the prognosis of breast cancer are essential. The 2′-5′-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antiviral enzymes, with their prognostic roles remain to be characterized. Methods: Prognostic values of OAS family members were assessed by multiple public available resources.Results: High mRNA expression of OAS1 and OAS3 were correlated with worse prognosis for all breast cancer patients, whereas OAS2 was associated with favorable prognosis. The prognostic values of OAS family in different clinicopathologic subtypes were also characterized. In DNA methylation level, cg12560128 in OAS2, cg06800840 and cg26328872 in OASL showed significant prognostic values. The mRNA expression of OAS members signature in high/low risk overall survival groups was opposite to the high/low risk recurrence free survival groups. Neutrophil cell exhibited highest correlation with all OAS members in tumor immune infiltrating estimation.Conclusions: This study provided new insight into the prognostic roles of OAS in breast cancer with potential mechanistic values.