Acrylamide (AA) is a heat-induced
toxicant, which can cause severe
damage to health. In the present study, SD rats were used to investigate
the potential therapeutic effects of allicin dietary supplementation
in the rats with AA-induced intestinal injury. The elevated expression
of occludin, claudin-1, zonula occludens-1 (ZO-1), mucin 2, and mucin
3 indicated that oral allicin alleviated the intestinal epithelial
barrier breakage induced by AA, compared with the AA-treated group.
In the gut microbiota, Bacteroides, Escherichia_Shigella, Dubosiella, and Alloprevotella related to the synthesis of short-chain fatty acids (SCFAs) were
negatively affected by AA, while allicin regulated cascade response
of the microbiota-SCFAs signaling to reverse the reduction of acetic
acid and propionic acid by AA treatment. Allicin also dramatically
down-regulated the expression of Toll-like receptor 4 (TLR4), myeloid
differentiation factor 88 (MyD88), NF-κB signaling pathway proteins,
and proinflammatory cytokines by promoting the production of SCFAs
in AA-treated rats. Allicin relieved the intestinal barrier injury
and inflammation caused by AA as evidenced by the regulation cascade
response of the microbiota-SCFAs-TLR4/MyD88/NF-κB signaling
pathway. In conclusion, allicin is highly effective in the treatment
and prevention of AA-induced intestinal injury.
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