Frustrations is a deep chronic sense or state of insecurity and dissatisfaction arising from unresolved problems or unfulfilled needs. This study delved on the lived experiences of nurses’ frustrations particularly in the clinical settings. The research design utilized a qualitative descriptive phenomenological study in the public and private tertiary hospitals in Cebu City, Philippines employing millennial nurses. Thus, purposive sampling and an in-depth semi-structured method was utilized. Data were analyzed using Colaizzi’s process for phenomenological data analysis. The results of the study emerged five major themes from the extracted statements specifically: (1) challenging experience, (2) controlling experience, (3) cold-shouldering experience, (4) censuring experience and (5) unvalued experience. The lived experiences of the millennia nurses significantly revealed their thoughts and feelings as a result of frustrations encounters in the workplace. To address the findings, it is best for the clinical nurse managers and leaders to be vigilant on the situations that may cause frustrations and find a way on how to deal without putting stigma to the millennial nurses in the clinical setting and continually redesigning the system to adapt to ongoing and future challenges. It is recommended that the nurse managers and administration may explore tailor-fit approaches and programs in the workplace to address reducing, preventing and eliminating frustrations of nurses, to improve policies in the workplace particularly in addressing related educational development, participation in professional trainings, autonomy in nursing practice, and workloads, the academician may enhance the policy improvement by conducting research related to conflict and frustrations, and lastly the future researchers may use the findings for further studies in order to deepen the understanding of frustrations among nurses.