This retrospective study analyzes the complications and the problems developed during and after pedicle screw fixation in patients with spinal disorders and trauma. One hundred twelve patients were treated using the Cotrel-Dubousset pedicle screw fixation system for degenerative disease (57 patients), trauma (42 patients), infection (eight patients), and tumor (five patients) of the lumbar or thoracolumbar spine. The average age of the patients was 47 years and the average followup was 35 months. Forty-seven general complications were seen in 41 patients (36.5%). In addition, hardware failures were observed in 12 patients (10.7%), junctional problems were seen in five patients (4.5%), problems in the instrumented segments were seen in 39 patients (34.7%), and problems of balance occurred in five patients (4.5%). Although the rate of the reported complications was high, the final outcome of the patients was not affected significantly. Placement of the pedicle screws in the thoracolumbar and lumbar spine is a technically demanding procedure. It should be used by experienced and qualified surgeons who are aware of the pitfalls associated with its use.

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Background: Apart from their main function as oxygen carriers in vertebrates, erythrocytes are also involved in immune regulation. By circulating throughout the body, the erythrocytes are exposed and interact with tissues that are damaged as a result of a disease. Methods: In this study, we summarize the literature regarding the contribution of erythrocytes to immune regulation and metabolism. Results: Under the circumstances of a disease state, the erythrocytes may lose their antioxidant capacity and release Damage Associated Molecular Patterns, resulting in regulation of innate and adaptive immunity. In addition, the erythrocytes scavenge and affect the levels of chemokines, circulating cell-free mtDNA and C3b attached immune complexes. Furthermore, through surface molecules, erythrocytes control the function of T lymphocytes, macrophages and dendritic cells. Through an array of enzymes, red blood cells contribute to the pool of blood’s bioactive lipids. Finally, the erythrocytes contribute to reverse cholesterol transport, through various mechanisms. Conclusion: Our study is highlighting overlooked molecular interactions between erythrocytes and immunity and metabolism, which could lead to the discovery of potent therapeutic targets for immunometabolic diseases.

In this work, a 3D numerical study on the influence of the spanwise distribution of tubercles on a unmanned aerial vehicle wing is presented. The idea of using tubercles in aeronautics comes from the humpback whale (Megaptera novaeangliae) which has a characteristic flipper, with a spanwise scalloped leading edge, creating an almost sinusoidal shape, consisting of bumps called tubercles. The whale uses this layout in order to achieve high underwater maneuverability. Early experimental research showed a great potential in enhancing the 3D aerodynamic characteristics of a wing. Most of the existing experimental results concern infinite wings (2D) models and are accompanied with substantial loss in lift and increase in drag in pre-stall region. On the other hand, 3D finite models have displayed a better overall aerodynamic performance (increased lift and moment, but also, decreased drag). At a range of Reynolds number between 500,000 and 1,000,000 (based on the mean chord of the flipper), tubercles act as virtual fences, introducing a pair of counter rotating vortices that delays the stall of the flipper, a phenomenon that the whales exploit to perform sharp turns and catch their prey. The aforementioned Reynolds number range is the same as the operational Reynolds number for typical unmanned aerial vehicles. To assess the influence of the tubercles installation on UAV wings, a full 3D computational study is carried-out with the use of CFD tools which at a first phase are validated and calibrated with the available literature experimental data. Then, computations are performed for different spanwise tubercles distributions. The results show that there is a noticeable potential on controlling the flow on the wings of a UAV operating in a Reynolds number range between 500,000 and 1,000,000 (based on UAV’s wing mean chord), which can lead to an aerodynamic performance and efficiency increase.

In this work, the development of a conceptual design methodology of an innovative aircraft configuration, known as box wing, is presented. A box wing aircraft is based on a continuous-surface nonplanar wing formation with no wing-tips. The A320 medium range conventional cantilever wing aircraft is used as both the reference aircraft and the main competitor of the box wing aircraft. Based on the A320 characteristics and dimensions, a complete aerodynamic analysis of the box wing configuration is made by means of layout design and computational fluid dynamics studies, highlighting the aerodynamic and operating advantages of the box wing configuration compared to the A320 aircraft. The aspect ratio and the Oswald factor of a box wing aircraft differ significantly from the corresponding ones of A320 and provide increased aerodynamic performance. The increased aerodynamic performance leads by consequence, to lower fuel consumption, thus allowing longer range for the same payload or greater payload for the same range, contributing to the efforts for greener environment. In this work, the design methodology begins by estimating the critical initial design parameters, such as aspect ratio, dihedral angle, sweep angle, and taper ratio, which are continuously refined via an iterative process based on a conceptual design study. Various flying scenarios are studied using computational fluid dynamics and analytical calculations, in order to compare the performance of the box wing and the conventional A320, having always the same mission and payload conditions. The conceptual results show that the novel box wing configuration has considerable aerodynamic performance advantages compared to the conventional A320 aircraft.