The study sought to empirically determine the prospects of TQM implementation in the design and production of slit and kaba in small to medium garment production enterprises in Ghana. The quantitative research design was adopted y. A total of 138 participants were purposively sampled from the population of small and medium-scale fashion enterprises in the Accra metropolis. A questionnaire was used as the main data collection instrument. The study discovered that TQM is fundamental to achieving high-quality products and customer satisfaction and retention. TQM results in an increase in sales, effective customer service coupled with cost reduction, and improved production practices, all will inure to the benefit and prospects of the production houses. It was, therefore, recommended that government should introduce a policy to include content on TQM as part of the curriculum of Higher Fashion Education in Ghana.