7 of 8 dogs receiving combination drug therapy consisting of flucytosine together with amphotericin B and/or a triazole for cryptococcosis or aspergillosis developed cutaneous or mucocutaneous eruptions during the course of treatment. Lesions resolved in all cases following discontinuation of flucytosine despite continued administration of other antifungals, suggesting the eruption was referable primarily to the flucytosine component of therapy. Lesions developed 13 to 41 days (median 20 days) after commencing flucytosine (105 to 188 mg/kg/day divided and given every 8 h; median dose rate 150 mg/kg/day). The cumulative dose of flucytosine given prior to the first signs of the drug eruption ranged from 1.7 to 6.8 g/kg (median 2.3 g/kg). The eruptions consisted of depigmentation, followed by ulceration, exudation and crust formation. The scrotum was affected in all 4 male dogs, the nasal plane in 6 of 7 cases, while the lips, vulva, external ear canal and integument were involved in a smaller number of cases. There was considerable variation in the severity of lesions, with changes being most marked when flucytosine was continued for several days after lesions first appeared. Some dogs experienced malaise and inappetence in association with the suspected drug eruption. Healing took a variable period, typically in excess of 2 weeks after discontinuing flucytosine, with up to 2 months being required for total resolution of the lesions. All lesions resolved eventually without scarring or permanent loss of pigment.
The first report of a successful endovascular repair of a popliteal artery aneurysm was described in 1994. Since then, few series with not many cases have been published. Next, the authors describe two cases of successful endovascular repair of bilateral popliteal artery aneurysm.
Treatment of arterial traumatic injuries is usually performed with conventional revascularization techniques. However, vascular injuries can increasingly be repaired efficiently through minimally invasive procedures. We report four cases of extremity arterial trauma treated by endovascular techniques in a reference center. All patients showed satisfactory development over a 15-month follow-up. We suggest that endovascular therapy is a promising alternative to surgery for selected patients with extremity arterial trauma.Keywords: Vascular trauma, pseudoaneurysm, ischemia, emergency treatment.
RESUMOGeralmente o tratamento das lesões arteriais traumáticas é realizado com técnicas tradicionais de revascularização. Cada vez mais, porém, as lesões vasculares podem ser corrigidas com eficiência por meio de procedimentos minimamente invasivos. Nós descrevemos quatro casos de trauma arterial dos membros que foram tratados por técnicas endovasculares num centro de referência. Todos os pacientes evoluíram satisfatoriamente durante o seguimento de 15 meses. Nós sugerimos que o tratamento endovascular é uma alternativa promissora em relação à cirurgia para pacientes selecionados com trauma arterial dos membros.
Palavras-chave:Trauma vascular, pseudo-aneurisma, isquemia, tratamento de urgência.
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