Relations between sustained attentional and disattentional abilities and hypnotic susceptibility (Harvard Group Scale of Hypnotic Susceptibility: Form A; Stanford Hypnotic Susceptibility Scale: Form C) were examined in 38 low (0-3) and 39 highly (10-12) hypnotizable college students. Highs showed greater sustained attention on Necker cube and autokinetic movement tasks and self-reported greater absorption (Tellegen Absorption Scale) and extremely focused attentional (Differential Attentional Processes Inventory) styles. Hypnotizability was unrelated to dichotic selective attention (A. Karlin, 1979) and random number generation (C. Graham & F. J. Evans, 1977) tasks. Discriminant analysis correctly classified 74% of the lows and 69% of the highs. Results support H. J. Crawford and J. H. Gruzelier's (1992) neuropsychophysiological model of hypnosis that proposes that highly hypnotizable persons have a more efficient far frontolimbic sustained attentional and disattentional system.

γ-aminobutyric acid (GABA) begins as the key excitatory neurotransmitter in newly forming circuits, with chloride efflux from GABA type A receptors (GABARs) producing membrane depolarization, which promotes calcium entry, dendritic outgrowth and synaptogenesis. As development proceeds, GABAergic signaling switches to inhibitory hyperpolarizing neurotransmission. Despite the evidence of impaired GABAergic neurotransmission in neurodevelopmental disorders, little is understood on how agonist-dependent GABAR activation controls the formation and plasticity of GABAergic synapses. We have identified a weakly depolarizing and inhibitory GABAR response in cortical neurons that occurs during the transition period from GABAR depolarizing excitation to hyperpolarizing inhibitory activity. We show here that treatment with the GABAR agonist muscimol mediates structural changes that diminish GABAergic synapse strength through postsynaptic and presynaptic plasticity via intracellular Ca stores, ERK and BDNF/TrkB signaling. Muscimol decreases synaptic localization of surface γ2 GABARs and gephyrin postsynaptic scaffold while β2/3 non-γ2 GABARs accumulate in the synapse. Concurrent with this structural plasticity, muscimol treatment decreases synaptic currents while enhancing the γ2 containing benzodiazepine sensitive GABAR tonic current in an ERK dependent manner. We further demonstrate that GABAR activation leads to a decrease in presynaptic GAD65 levels via BDNF/TrkB signaling. Together these data reveal a novel mechanism for agonist induced GABAergic synapse plasticity that can occur on the timescale of minutes, contributing to rapid modification of synaptic and circuit function.

This study investigated the relationships of metal levels and metal combinations to children's classroom behavior. Hair-metal concentrations of lead, arsenic, mercury, cadmium, and aluminum were determined in 80 randomly selected elementary-age children, who were also rated by their classroom teacher on the Walker Problem Behavior Identification Checklist (WPBIC). Parents were interviewed to control for confounding variables that may have affected behavioral development. Regression analysis indicated that the set of metals was significantly related to increased scores on four of the five WPBIC subscales and on the total scale, with lead being a major contributor to four of the six dependent measures. Metal combinations were significantly related to increased scores on the WPBIC subscales measuring acting-out, disturbed peer relations, and immaturity, and on the total scale. A continuing reexamination of metal poisoning concentrations is needed because metal levels and metal combinations previously thought harmless may be associated with nonadaptive classroom behavior.

Objectives. We examined findings from the 2008 National Association of Local Boards of Health Survey to provide information about this understudied entity to the public health community.Methods. The survey instrument consisted of 196 items covering five parts: (1) demographics; (2) composition and organizational structure; (3) roles, responsibilities, and authorities; (4) telecommunications infrastructure; and (5) concerns and needs. The survey was sent to chairs of local boards of health (LBHs) in 2008 (n53,276). After six months of follow-ups and reminders, and a month of data cleaning and screening, the final sample consisted of 870 respondents, for a return rate of 27%.results. LBHs tend to represent smaller communities and are primarily appointed. Governing and policy-making boards are more prevalent than advisory boards. Most boards do not have official websites or e-mail addresses of board members available to the public; however, most report the capability to receive training via webcasts. Boards express concerns and needs in a variety of areas, particularly public health law, strategic planning, and accreditation.conclusions. Little is known about the more than 3,000 LBHs across the United States that are often charged with making and enforcing public health law. This article is a first step toward providing the public health community with information about LBHs based on survey data.