oxygen therapy in circulatory failure. When this disorder arises as a result of acute myocardial infarction, the administration of oxygen may relieve dyspnea, cyanosis and cardiac pain and tide the patient over the initial crucial stages of the attack. The diminution in

Furthermore, it has been demonstrated that induced anoxemia in certain patients with coronary insufficiency is attended by appreciable electrocardiographic alterations. '' 12 In such patients an opportunity might be afforded to study the modifying action of certain drugs.'3 The ideal subject for observation would be one in whom, under carefully controlled conditions, the use of a standard test would repeatedly produce electrocardiographic changes of the same order.Having found a case fulfilling these criteria, an investigation of the comparative vasodilator effects of papaverine, nitroglycerin, and ethyl alcohol was undertaken, utilizing the Master "two-step" test. '

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