Melanoma is an aggressive but easily preventable cancer. However, it may have a highly atypical presentation which makes early detection more difficult. This case report discusses a 25-year-old patient with a rare case of melanoma developing underneath the nail of the first toe. The case was originally diagnosed as trauma due to its rarity and epidemiological unlikeliness, however through the patient’s persistence for alternative opinions the correct diagnosis was eventually made. However, this led to an amputation as well as more intense, invasive treatment. There were several points on history (duration of the lesion, appearance of the lesion, and lack of healing progress) which when combined with the lesion’s physical appearance should have made such a presentation suspicious for a more malignant cause. This case highlights the importance of early detection in the prognosis and treatment of patients with cancer, the importance of considering all aspects of a history and physical exam, and the importance of listening to and addressing a patient’s concerns. As always, more common diagnoses should be first considered, but when the story does not match up with the presentation, one should move past the horses to consider the zebras.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.