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I. Operational Aspects By CHIARLES E. KoIHLER* DDT applied as a residual spray hlas been used sucGcessfully for the control of adult Anopheles in malaria control programs in many parts of the world. Up to the present time, lhowever, data on its effectiveness against mosquitoes of other genera have been scanty, and have been collected incidental to anoplheline control work. Reeves, Washburn, and Hammon (1) reported results from thle experimental spraying of natural resting places of Culex tarsalis in California. De Caires (2) indicated that control of Aedes aegypti was easily achieved by spraying houses with DDT in British Guiana bllt that Culex quinquefasciatus was far less susceptible to DDT. Giglioli (3) demonstrated that adult Culex are the most resistant to DDT of the species studied by the MIalaria Service in Britislh Guiana. This same author (4) reports that in British Guiana A. aegypti is at preseint under control by routine measures but that the control of C. quinquefasciatus (fatigans) presents a more difficult problem. The present work constitutes the first attempt to use DDT residuial house spraying for the control of C. quinquefasciatus to prevent transmission of WVuchereria bancrofti, the causative organism of humain filariasis in the Caribbean region. This program was initiated on St. Croix, Virgiii Islands, October 9, 1946, as a cooperative project of the Selool of Public Health of Columbia University, the Public Health Service, and the 'Municipal Health Department of St. Croix. During blood surveys conducted by Dr. H. W. Brown, and his associates of Columbia University, it was found that 13.3 percent of 1,311 clhildren of scliool age had microfilariae of l'. bancrofti. A concurrent mosquito dissection suirvey of 2,244 C. quinquefasciatus revealed that 7.9 percent were positive for W. bancrofti and 2.3 percent of 867 A. aegylpti were positive. The accompanying report, Results, by Dr. H. WV. Brown and Dr. Roger W. Williams gives detailed medical and entomological iliforma

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