Acidity Constants of Tetracycline Antibiotics 4155 droquinone is oxidized to %quinone. Then the differences in Cu, not extracted from the solution by the cation-exchange materials, would indicate a higher formation constant for Cu-o-quinone than for Cu-p-quinone.The apparent effect of denaturation of the tyrosinase on the Cu + + complexed, as shown in Table II, is probably related to the amount of o-quinone formed rather than change in the enzyme. The ap-parent effect of time of addition of Cu64S04 to the oxidizing solution on the amount of CuT+ complexed is probably due to the polymerization of the o-quinone and the decrease in active binding sites. That is, if the Cu++ was present at the time of formation of o-quinone, a greater amount was complexed than if the o-quinone was allowed to begin polymerization prior to addition of the Cu64S04.

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