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Listeriosis is an illness caused by the germ Listeria monocytogenes. Generally, humans are infected with listeriosis after eating contaminated food. Listeriosis mostly affects people with weakened immune systems, pregnant women and newborns. In this paper, a model describing the dynamics of Listeriosis is developed and analysed using ordinary differential equations. The model was analysed both quantitatively and qualitatively for its local and global stability, basic reproductive number and parameter contributions to the basic reproductive number to understand the impact of each parameter on the disease spread. The Listeriosis model has been extended to include time dependent control variables such as treatment of both humans and animals, vaccination and education of humans. Pontryagin's Maximum Principle was introduced to obtain the best optimal control strategies required for curbing Listeriosis infections. Numerical simulation was performed and the results displayed graphically and discussed. Cost effectiveness analysis was conducted using the intervention averted ratio (IAR) concepts and it was revealed that the most effective intervention strategy is the treatment of infected humans and animals.

This paper shows that discrete linear equations with Hilbert matrix operator, circulant matrix operator, conference matrix operator, banded matrix operator, TST matrix operator, and sparse matrix operator are ill-posed in the sense of Hadamard. Gauss least square method (GLSM), QR factorization method (QRFM), Cholesky decomposition method (CDM), and singular value decomposition (SVDM) failed to regularize these ill-posed problems. This paper introduces the eigenspace spectral regularization method (ESRM), which solves ill-posed discrete equations with Hilbert matrix operator, circulant matrix operator, conference matrix operator, and banded and sparse matrix operator. Unlike GLSM, QRFM, CDM, and SVDM, the ESRM regularizes such a system. In addition, the ESRM has a unique property, the norm of the eigenspace spectral matrix operator κ K = K − 1 K = 1 . Thus, the condition number of ESRM is bounded by unity, unlike the other regularization methods such as SVDM, GLSM, CDM, and QRFM.

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In this paper, it is shown that discrete equations with Hilb ert matrix operator, circulant matrix operator, conference matrix operator, banded matrix operator, and sparse matrix operator are ill-posed in the sense of Hadamard. These ill-posed problems cannot be regularized by Gauss Least Square Method (GLSM), QR Factorization Method (QRFM), Cholesky Decomposition Method (CDM) and Singular Value Decomposition (SVDM). To overcome the limitations of these methods of regularization, an Eigenspace Spectral Regularization Method (ESRM) is introduced which solves ill-p os ed discrete equations with Hilb ert matrix operator, circulant matrix operator, conference matrix operator, banded matrix operator, and sparse matrix operator. Unlike GLSM, QRFM, CDM, and SVDM, the ESRM regularize such a system. In addition, the ESRM has a unique property, the norm of the eigenspace spectral matrix operator κ (K) = ||K − 1K|| = 1. Thus, the condition number of ESRM is bounded by unity unlike the other regularization methods such as SVDM, GLSM, CDM, and QRFM.